Blood culture quality and turnaround time of clinical microbiology laboratories in Chinese Teaching Hospitals: A multicenter study

Liu, Wanting1; Liao, Kang2; Wu, Jinsong3,4; Liu, Suling5; Zheng, Xin6; Wen, Weihong7; Fu, Liang8; Fan, Xiaoyi9; Yang, Xiao10; Hu, Xiumei11; Jiang, Yueting12; Wu, Kuihai13; Guo, Zhusheng14; Li, Yang15; Liu, Weiyang16; Cai, Mufa17; Guo, Zhaowang18; Guo, Xuguang19; Lu, Jinghui20; Chen, Enzhong1; Zhou, Hongwei1; Chen, Dingqiang1

2024

10.1002/jcla.25008

JOURNAL OF CLINICAL LABORATORY ANALYSIS   影响因子和分区

0887-8013

1098-2825

["PurposeBlood culture (BC) remains the gold standard for the diagnosis of bloodstream infections. Improving the quality of clinical BC samples, optimizing BC performance, and accelerating antimicrobial susceptibility test (AST) results are essential for the early detection of bloodstream infections and specific treatments.MethodsWe conducted a retrospective multicenter study using 450,845 BC specimens from clinical laboratories obtained from 19 teaching hospitals between 1 January 2021 and 31 December 2021. We evaluated key performance indicators (KPIs), turnaround times (TATs), and frequency distributions of processing in BC specimens. We also evaluated the AST results of clinically significant isolates for four different laboratory workflow styles.ResultsAcross the 10 common bacterial isolates (n = 16,865) and yeast isolates (n = 1011), the overall median (interquartile range) TATs of AST results were 2.67 (2.05-3.31) and 3.73 (2.98-4.64) days, respectively. The specimen collections mainly occurred between 06:00 and 24:00, and specimen reception and loadings mainly between 08:00 and 24:00. Based on the laboratory workflows of the BCs, 16 of the 19 hospitals were divided into four groups. Time to results (TTRs) from specimen collection to the AST reports were 2.35 (1.95-3.06), 2.61 (1.98-3.32), 2.99 (2.60-3.87), and 3.25 (2.80-3.98) days for groups I, II, III, and IV, respectively.ConclusionThis study shows the related BC KPIs and workflows in different Chinese hospitals, suggesting that laboratory workflow optimization can play important roles in shortening time to AST reports and initiation of appropriate timely treatment.","The median turnaround times from specimen collection to the AST reports were 2.35, 2.61, 2.99, and 3.25 days for laboratory workflow groups I, II, III, and IV, respectively. There are significant differences in the quality and process of blood culture among different teaching hospitals in Guangdong Province, China. To improve the efficiency and accuracy of blood culture testing, it is recommended that further optimization measures be considered for the numbers and types of blood culture bottles used, as well as the laboratory workflows in these hospitals.image"]

blood culture clinical microbiology laboratory key performance indicators laboratory workflow turnaround time

SCI

英语

其他

Medical Laboratory Technology

Medical Laboratory Technology

WOS:001144085300001

WILEY

CLINICAL MEDICINE

Web of Science

1.Southern Med Univ, Zhujiang Hosp, Microbiome Med Ctr, Dept Lab Med, Guangzhou, Guangdong, Peoples R China
2.Sun Yat sen Univ, Affiliated Hosp 1, Dept Lab Med, Guangzhou, Guangdong, Peoples R China
3.Jinan Univ, Southern Univ Sci & Technol, Clin Med Coll 2, Affiliated Hosp 1,Dept Neurol,Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
5.Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Clin Lab, Guangzhou, Guangdong, Peoples R China
6.Sun Yat sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou, Guangdong, Peoples R China
7.Guangzhou Med Univ, Affiliated Hosp 6, Qingyuan Peoples Hosp, Dept Lab Med, Qingyuan, Guangdong, Peoples R China
8.Southern Med Univ, Affiliated Hosp 5, Dept Lab Med, Guangzhou, Guangdong, Peoples R China
9.Jinan Univ, Affiliated Hosp 1, Clin Microbiol Lab, Guangzhou, Guangdong, Peoples R China
10.Guangzhou First Peoples Hosp, Dept Lab Med, Guangzhou, Guangdong, Peoples R China
11.Southern Med Univ, Nanfang Hosp, Dept Lab Med, Guangzhou, Guangdong, Peoples R China
12.Guangzhou Med Univ, Affiliated Hosp 1, Dept Lab Med, Guangzhou, Guangdong, Peoples R China
13.First Peoples Hosp Foshan, Dept Lab Med, Foshan, Guangdong, Peoples R China
14.Dept Dongguan Tungwah Hosp, Clin Microbiol Lab, Dongguan, Guangdong, Peoples R China
15.Zhongshan City Peoples Hosp, Dept Lab Med, Zhongshan, Guangdong, Peoples R China
16.Third Peoples Hosp Huizhou, Clin Lab, Huizhou, Guangdong, Peoples R China
17.Guangdong Med Univ, Affiliated Hosp, Ctr Lab Med, Zhanjiang, Guangdong, Peoples R China
18.Sun Yat Sen Univ, Affiliated Hosp 5, Clin Lab, Zhuhai 519000, Guangdong, Peoples R China
19.Guangzhou Med Univ, Affiliated Hosp 3, Dept Clin Lab Med, Guangzhou, Guangdong, Peoples R China
20.Guangdong Pharmaceut Univ, Affiliated Hosp 1, Sch Clin Med, Lab Med Dept, Guangzhou, Guangdong, Peoples R China

Liu, Wanting,Liao, Kang,Wu, Jinsong,et al. Blood culture quality and turnaround time of clinical microbiology laboratories in Chinese Teaching Hospitals: A multicenter study[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2024,38(1-2).

Liu, Wanting.,Liao, Kang.,Wu, Jinsong.,Liu, Suling.,Zheng, Xin.,...&Chen, Dingqiang.(2024).Blood culture quality and turnaround time of clinical microbiology laboratories in Chinese Teaching Hospitals: A multicenter study.JOURNAL OF CLINICAL LABORATORY ANALYSIS,38(1-2).

Liu, Wanting,et al."Blood culture quality and turnaround time of clinical microbiology laboratories in Chinese Teaching Hospitals: A multicenter study".JOURNAL OF CLINICAL LABORATORY ANALYSIS 38.1-2(2024).