Dronedarone Enhances the Antibacterial Activity of Polymyxin B and Inhibits the Quorum Sensing System by Interacting with LuxS

Cui, Ruiqin1,2,3; Zhang, Jinyong4; Liu, Xiaodi5; Hu, Chunxia1,2,3; Zhou, Fan1,2,3; Zhang, Min1; Wang, Xiao6; Zou, Quanming4; Huang, Wei3,7,8

2024-02-06

10.1021/acsinfecdis.3c00591

ACS INFECTIOUS DISEASES   影响因子和分区

2373-8227

Quorum sensing (QS) is considered an appealing target for interference with bacterial infections. beta-Adrenergic blockers are promising anti-QS agents but do not have antibacterial activity. We assessed the potential ability of adrenergic receptor inhibitors to enhance the antibacterial activity of polymyxin B (PB) against Klebsiella pneumoniae and determined that dronedarone has the most potent activity both in vitro and in vivo. We found that dronedarone increases the thermal stability of LuxS, decreases the production of AI-2, and affects the biofilm formation of K. pneumoniae. We also identified the direct binding of dronedarone to LuxS. However, the mechanism by which dronedarone enhances the antibacterial activity of PB has not been elucidated and is worthy of further exploration. Our study provides a basis for the future development of drug combination regimens.

Klebsiella pneumoniae polymyxin B quorumsensing system LuxS AI-2 dronedarone

SCI

英语

第一 ; 通讯

Pharmacology & Pharmacy ; Infectious Diseases

Chemistry, Medicinal ; Infectious Diseases

WOS:001163353600001

AMER CHEMICAL SOC

Web of Science

1.Southern Univ Sci & Technol, Affiliated Hosp 1, Clin Med Coll 2, Antimicrobial Drug Screening Lab,Shenzhen Inst Res, Shenzhen 518020, Peoples R China
2.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Med Lab, Shenzhen 518020, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
4.Third Mil Med Univ, Coll Pharm, Natl Engn Res Ctr Immunol Prod, Dept Microbiol & Biochem Pharm, Chongqing 400038, Peoples R China
5.Southern Univ Sci & Technol, Affiliated Hosp 1, Clin Med Coll 2, Dept Infect Dis,Shenzhen Peoples Hosp,Jinan Univ, Shenzhen 518020, Peoples R China
6.Southern Univ Sci & Technol, Affiliated Hosp 1, Clin Med Coll 2, Dept Pharm,Shenzhen Peoples Hosp,Jinan Univ, Shenzhen 518020, Peoples R China
7.Jinan Univ, Clin Med Coll 2, Dept Gen Surg, Dept Med Lab,Shenzhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China
8.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Div Hepatobiliary & Pancreas Surg,Dept Gen Surg, Shenzhen 518020, Guangdong, Peoples R China

Cui, Ruiqin,Zhang, Jinyong,Liu, Xiaodi,et al. Dronedarone Enhances the Antibacterial Activity of Polymyxin B and Inhibits the Quorum Sensing System by Interacting with LuxS[J]. ACS INFECTIOUS DISEASES,2024,10(3).

Cui, Ruiqin.,Zhang, Jinyong.,Liu, Xiaodi.,Hu, Chunxia.,Zhou, Fan.,...&Huang, Wei.(2024).Dronedarone Enhances the Antibacterial Activity of Polymyxin B and Inhibits the Quorum Sensing System by Interacting with LuxS.ACS INFECTIOUS DISEASES,10(3).

Cui, Ruiqin,et al."Dronedarone Enhances the Antibacterial Activity of Polymyxin B and Inhibits the Quorum Sensing System by Interacting with LuxS".ACS INFECTIOUS DISEASES 10.3(2024).