Egg consumption and risk of coronary artery disease, potential amplification by high genetic susceptibility: a prospective cohort study

Xia, Xue1,2,3,4; Liu, Fangchao1,2; Huang, Keyong1; Chen, Shufeng1; Li, Jianxin1; Cao, Jie1; Yang, Xueli5; Liu, Xiaoqing6,7; Shen, Chong8; Yu, Ling9; Zhao, Yingxin10; Zhao, Liancheng1; Li, Ying1; Hu, Dongsheng11,12; Huang, Jiangfeng1; Lu, Xiangfeng1,2; Gu, Dongfeng1,2,13

2023-10-01

10.1016/j.ajcnut.2023.06.009

AMERICAN JOURNAL OF CLINICAL NUTRITION   影响因子和分区

0002-9165

1938-3207

Background: Remarkable heterogeneity has been observed among population-based studies on egg consumption and risk of coronary artery disease (CAD). Whether genetic susceptibility serves as a potential explanation for this inconsistency remains unknown. Objectives: We performed a prospective cohort study to investigate the association of egg consumption with incident CAD at different genetic susceptibilities. Methods: We included 34,111 participants without CAD at baseline from the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China. Egg consumption was assessed with food frequency questionnaires. Genetic susceptibility was quantified by a predefined polygenic risk score (PRS) with 540 genetic variants. The hazard ratio (HR) and 95% confidence interval (95% CI) of incident CAD associated with egg consumption and PRS were estimated using the Cox proportional hazards models. Results: Over a median 11.7 y of follow-up, 1,128 incident cases of CAD were recorded. Both higher egg consumption and increased PRS were related to higher risk of CAD. When stratified by genetic risk, each increment of 3 eggs/wk was associated with a 5% higher risk of CAD for participants at low to intermediate genetic risk (HR: 1.05; 95% CI: 1.01, 1.09), whereas risk increased to HR 1.10 (95% CI: 1.05, 1.16) for those at high genetic risk; a significant synergistic interaction was also indicated at both multiplicative (P-interaction = 0.007) and additive (relative excess risk: 0.73; 95% CI: 0.24, 1.22) scales. When the joint effect was examined, in comparison with those at low to intermediate genetic risk and consuming <1 egg/wk, the HR (95% CI) was 2.95 (2.41, 3.62) for participants with high genetic risk and consumption of >= 10 eggs/wk, and the corresponding standardized 10-y CAD rates increased from 1.37% to 4.24%. Conclusions: Genetic predisposition may synergistically interact with egg consumption in relation to increased CAD risk. PRS-stratified recommendations on egg consumption may help formulate personalized nutrition policies.

egg consumption polygenic risk score coronary artery disease cohort study interaction effect

SCI

英语

通讯

Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences["2021-I2M-1-010","2019-I2M-2-003","2017-I2M-1-004"] ; National Key Research and Development Program of China["2018YFE0115300","2017YFC0211700","2021YFC2500503"] ; National High Level Hospital Clinical Research Funding["2022-GSP-GG-1","2022-GSP-GG-2","2023-GSP-RC-19"] ; National Natural Science Foundation of China["82030102","12126602","91857118"] ; Taikang Yicai Public Health and Epidemic Control Fund[TKYC-GW-2020] ; National Clinical Research Center for Cardiovas-cular Diseases, Fuwai Hospital, CAMS[NCRC2020006] ; Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancers, CAMS[2019RU038]

Nutrition & Dietetics

Nutrition & Dietetics

WOS:001165007200001

ELSEVIER SCIENCE INC

CLINICAL MEDICINE

Web of Science

1.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing, Peoples R China
2.Chinese Acad Med Sci, Key Lab Cardiovasc Epidemiol, Beijing, Peoples R China
3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China
4.Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
5.Tianjin Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tianjin Key Lab Environm Nutr & Publ Hlth, Tianjin, Peoples R China
6.Guangdong Prov Peoples Hosp, Div Epidemiol, Guangzhou, Peoples R China
7.Cardiovasc Inst, Guangzhou, Peoples R China
8.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Peoples R China
9.Fujian Prov Hosp, Dept Cardiol, Fuzhou, Peoples R China
10.Shandong Acad Med Sci, Inst Basic Med, Cardiocerebrovasc Control & Res Ctr, Jinan, Shandong, Peoples R China
11.Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Hlth Stat, Zhengzhou, Peoples R China
12.Shenzhen Univ, Sch Publ Hlth, Dept Biostat & Epidemiol, Hlth Sci Ctr, Shenzhen, Peoples R China
13.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China

Xia, Xue,Liu, Fangchao,Huang, Keyong,et al. Egg consumption and risk of coronary artery disease, potential amplification by high genetic susceptibility: a prospective cohort study[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION,2023,118(4).

Xia, Xue.,Liu, Fangchao.,Huang, Keyong.,Chen, Shufeng.,Li, Jianxin.,...&Gu, Dongfeng.(2023).Egg consumption and risk of coronary artery disease, potential amplification by high genetic susceptibility: a prospective cohort study.AMERICAN JOURNAL OF CLINICAL NUTRITION,118(4).

Xia, Xue,et al."Egg consumption and risk of coronary artery disease, potential amplification by high genetic susceptibility: a prospective cohort study".AMERICAN JOURNAL OF CLINICAL NUTRITION 118.4(2023).