| 题名 | Mechanical strain regulates osteogenesis via Antxr1/LncRNA H19/Wnt/β-catenin axis |
| 作者 | |
| 通讯作者 | Xu, Jiake; Zou, Jun |
| 发表日期 | 2024-05-01
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| DOI | |
| 发表期刊 | |
| ISSN | 0021-9541
|
| EISSN | 1097-4652
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| 卷号 | 239期号:5 |
| 摘要 | Alleviating bone loss is an essential way to prevent osteoporotic fractures. Proper exercise improves bone density without the side effects of long-term medications, but the mechanism is unclear. Our study explored the role of Antxr1/LncRNA H19/Wnt/beta-catenin axis in the process of exercise-mediated alleviation of bone loss. Here we discovered that moderate-intensity treadmill exercise alleviates bone loss caused by ovariectomy and ameliorates bone strength accompanied by an increased lncRNA H19 expression. Concomitantly, Antxr1, a mechanosensitive protein was found downregulated by exercise but upregulated by ovariectomy. Interestingly, knockdown expression of Antxr1 increased lncRNA H19 expression and Wnt/beta-catenin signaling pathway in bone marrow mesenchymal stem cells, whereas overexpression of Antxr1 decreased lncRNA H19 expression and Wnt/beta-catenin signaling pathway. Hence, our study demonstrates the regulation of Antxr1/LncRNA H19/Wnt/beta-catenin axis in the process of mechanical strain-induced osteogenic differentiation, which provides further mechanistic insight into the role of mechanical regulation in bone metabolism. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
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| 资助项目 | The 2021 Capacity Building of Shanghai Universities["2021","21010503600"]
; Shanghai Key Laboratory of Human Sport Performance (Shanghai University of sport)[11DZ2261100]
; Shenyang Science and Technology Talent Special Project[RC230321]
; Shenzhen Medical Research Fund["B2302005","NSFC 82350710800","82374470"]
; NHMRC[APP1163933]
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| WOS研究方向 | Cell Biology
; Physiology
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| WOS类目 | Cell Biology
; Physiology
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| WOS记录号 | WOS:001162699100001
|
| 出版者 | |
| ESI学科分类 | MOLECULAR BIOLOGY & GENETICS
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| 来源库 | Web of Science
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/789296 |
| 专题 | 工学院_生物医学工程系 |
| 作者单位 | 1.Shanghai Univ Sport, Sch Exercise & Hlth, Shanghai, Peoples R China 2.Peoples Hosp Liaoning Prov, Dept Rehabil, Shenyang, Peoples R China 3.Southern Univ Sci & Technol, Dept Biomed Engn, Guangzhou, Peoples R China 4.Qingdao Univ Sci & Technol, Coll Phys Educ, Qingdao, Peoples R China 5.Yanshan Univ, Coll Phys Educ, Qinhuangdao, Peoples R China 6.Wenzhou Med Univ, Sch Sports Sci, Wenzhou, Peoples R China 7.Univ Western Australia, Sch Biomed Sci, Perth, WA, Australia 8.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Liu, Lifei,Guo, Jianmin,Tong, Xiaoyang,et al. Mechanical strain regulates osteogenesis via Antxr1/LncRNA H19/Wnt/β-catenin axis[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2024,239(5).
|
| APA |
Liu, Lifei.,Guo, Jianmin.,Tong, Xiaoyang.,Zhang, Miao.,Chen, Xi.,...&Zou, Jun.(2024).Mechanical strain regulates osteogenesis via Antxr1/LncRNA H19/Wnt/β-catenin axis.JOURNAL OF CELLULAR PHYSIOLOGY,239(5).
|
| MLA |
Liu, Lifei,et al."Mechanical strain regulates osteogenesis via Antxr1/LncRNA H19/Wnt/β-catenin axis".JOURNAL OF CELLULAR PHYSIOLOGY 239.5(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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