The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021

Zhang, Min1; Ma, Yingying1; Wang, Gang1; Wang, Zhenyan1; Wang, Qianying1; Li, Xin1; Lin, Feng1; Qiu, Jianping1; Chen, Daihong1; Shen, Yinzhong1; Zhang, Chiyu1; Lu, Hongzhou1,2

2024-03-01

10.1093/jac/dkad370

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY   影响因子和分区

0305-7453

1460-2091

Background HIV-1 drug resistance is a huge challenge in the era of ART.Objectives To investigate the prevalence and characteristics of acquired HIV-1 drug resistance (ADR) in Shanghai, China.Methods An epidemiological study was performed among people living with human immunodeficiency virus (PLWH) receiving ART in Shanghai from January 2017 to December 2021. A total of 8669 PLWH were tested for drug resistance by genotypic resistance testing. Drug resistance mutations (DRMs) were identified using the Stanford University HIV Drug Resistance Database program.Results Ten HIV-1 subtypes/circulating recombinant forms (CRFs) were identified, mainly including CRF01_AE (46.8%), CRF07_BC (35.7%), B (6.4%), CRF55_01B (2.8%) and CRF08_BC (2.4%). The prevalence of ADR was 48% (389/811). Three NRTI-associated mutations (M184V/I/L, S68G/N/R and K65R/N) and four NNRTI-associated mutations (V179D/E/T/L, K103N/R/S/T, V106M/I/A and G190A/S/T/C/D/E/Q) were the most common DRMs. These DRMs caused high-level resistance to lamivudine, emtricitabine, efavirenz and nevirapine. The DRM profiles appeared to be significantly different among different subtypes.Conclusions We revealed HIV-1 subtype characteristics and the DRM profile in Shanghai, which provide crucial guidance for clinical treatment and management of PLWH.

SCI

英语

通讯

National Natural Science Foundation of China["32170147","82072281","92169119"] ; Shanghai Science and Technology Committee["20MC1920100","21Y31900401"]

Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy

Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy

WOS:001154519700001

OXFORD UNIV PRESS

PHARMACOLOGY & TOXICOLOGY

Web of Science

1.Fudan Univ, Shanghai Clin Res Ctr Infect Dis HIV AIDS, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China
2.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Hosp 2, Shenzhen 518112, Guangdong, Peoples R China

Zhang, Min,Ma, Yingying,Wang, Gang,et al. The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,2024,79(3).

Zhang, Min.,Ma, Yingying.,Wang, Gang.,Wang, Zhenyan.,Wang, Qianying.,...&Lu, Hongzhou.(2024).The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021.JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,79(3).

Zhang, Min,et al."The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021".JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 79.3(2024).