题名 | The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021 |
作者 | |
通讯作者 | Lu, Hongzhou |
发表日期 | 2024-03-01
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DOI | |
发表期刊 | |
ISSN | 0305-7453
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EISSN | 1460-2091
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卷号 | 79期号:3 |
摘要 | Background HIV-1 drug resistance is a huge challenge in the era of ART.Objectives To investigate the prevalence and characteristics of acquired HIV-1 drug resistance (ADR) in Shanghai, China.Methods An epidemiological study was performed among people living with human immunodeficiency virus (PLWH) receiving ART in Shanghai from January 2017 to December 2021. A total of 8669 PLWH were tested for drug resistance by genotypic resistance testing. Drug resistance mutations (DRMs) were identified using the Stanford University HIV Drug Resistance Database program.Results Ten HIV-1 subtypes/circulating recombinant forms (CRFs) were identified, mainly including CRF01_AE (46.8%), CRF07_BC (35.7%), B (6.4%), CRF55_01B (2.8%) and CRF08_BC (2.4%). The prevalence of ADR was 48% (389/811). Three NRTI-associated mutations (M184V/I/L, S68G/N/R and K65R/N) and four NNRTI-associated mutations (V179D/E/T/L, K103N/R/S/T, V106M/I/A and G190A/S/T/C/D/E/Q) were the most common DRMs. These DRMs caused high-level resistance to lamivudine, emtricitabine, efavirenz and nevirapine. The DRM profiles appeared to be significantly different among different subtypes.Conclusions We revealed HIV-1 subtype characteristics and the DRM profile in Shanghai, which provide crucial guidance for clinical treatment and management of PLWH. |
相关链接 | [来源记录] |
收录类别 | |
语种 | 英语
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学校署名 | 通讯
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资助项目 | National Natural Science Foundation of China["32170147","82072281","92169119"]
; Shanghai Science and Technology Committee["20MC1920100","21Y31900401"]
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WOS研究方向 | Infectious Diseases
; Microbiology
; Pharmacology & Pharmacy
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WOS类目 | Infectious Diseases
; Microbiology
; Pharmacology & Pharmacy
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WOS记录号 | WOS:001154519700001
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出版者 | |
ESI学科分类 | PHARMACOLOGY & TOXICOLOGY
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来源库 | Web of Science
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引用统计 |
被引频次[WOS]:2
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成果类型 | 期刊论文 |
条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/789335 |
专题 | 南方科技大学第二附属医院 |
作者单位 | 1.Fudan Univ, Shanghai Clin Res Ctr Infect Dis HIV AIDS, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China 2.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Hosp 2, Shenzhen 518112, Guangdong, Peoples R China |
通讯作者单位 | 南方科技大学第二附属医院 |
推荐引用方式 GB/T 7714 |
Zhang, Min,Ma, Yingying,Wang, Gang,et al. The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,2024,79(3).
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APA |
Zhang, Min.,Ma, Yingying.,Wang, Gang.,Wang, Zhenyan.,Wang, Qianying.,...&Lu, Hongzhou.(2024).The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021.JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,79(3).
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MLA |
Zhang, Min,et al."The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021".JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 79.3(2024).
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