Hydrogel Loaded with Components for Therapeutic Applications in Hypertrophic Scars and Keloids

Zhong, Yixiu1,2; Zhang, Youfan3; Lu, Beibei1,2; Deng, Zhenjun1; Zhang, Zhiwen3; Wang, Qi2,3; Zhang, Jianglin1,2

2024

10.2147/IJN.S448667

INTERNATIONAL JOURNAL OF NANOMEDICINE   影响因子和分区

1178-2013

Hypertrophic scars and keloids are common fibroproliferative diseases following injury. Patients with pathologic scars suffer from impaired quality of life and psychological health due to appearance disfiguration, itch, pain, and movement disorders. Recently, the advancement of hydrogels in biomedical fields has brought a variety of novel materials, methods and therapeutic targets for treating hypertrophic scars and keloids, which exhibit broad prospects. This review has summarized current research on hydrogels and loaded components used in preventing and treating hypertrophic scars and keloids. These hydrogels attenuate keloid and hypertrophic scar formation and progression by loading organic chemicals, drugs, or bioactive molecules (such as growth factors, genes, proteins/peptides, and stem cells/exosomes). Among them, smart hydrogels (a very promising method for loading many types of bioactive components) are currently favoured by researchers. In addition, combining hydrogels and current therapy (such as laser or radiation therapy, etc.) could improve the treatment of hypertrophic scars and keloids. Then, the difficulties and limitations of the current research and possible suggestions for improvement are listed. Moreover, we also propose novel strategies for facilitating the construction of target multifunctional hydrogels in the future.

hydrogel wound healing hypertrophic scar keloid

SCI

英语

通讯

National Natural Science Foundation of China["82073019","82073018","82202851"] ; Shenzhen Science and Technology Innovation Commission, China (Natural Science Foundation of Shenzhen)["JCYJ20210324113001005","JCYJ20210324114212035","JCYJ20220530151817038"]

Science & Technology - Other Topics ; Pharmacology & Pharmacy

Nanoscience & Nanotechnology ; Pharmacology & Pharmacy

WOS:001153010100001

DOVE MEDICAL PRESS LTD

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Dermatol, Guangzhou, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
3.Southern Med Univ, Nanfang Hosp, Dept Dermatol, Guangzhou, Peoples R China

Zhong, Yixiu,Zhang, Youfan,Lu, Beibei,et al. Hydrogel Loaded with Components for Therapeutic Applications in Hypertrophic Scars and Keloids[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2024,19.

Zhong, Yixiu.,Zhang, Youfan.,Lu, Beibei.,Deng, Zhenjun.,Zhang, Zhiwen.,...&Zhang, Jianglin.(2024).Hydrogel Loaded with Components for Therapeutic Applications in Hypertrophic Scars and Keloids.INTERNATIONAL JOURNAL OF NANOMEDICINE,19.

Zhong, Yixiu,et al."Hydrogel Loaded with Components for Therapeutic Applications in Hypertrophic Scars and Keloids".INTERNATIONAL JOURNAL OF NANOMEDICINE 19(2024).