Copper-Based Single-Atom Nanozyme System Mimicking Platelet Cells for Enhancing the Outcome of Radioimmunotherapy

Chen, Cheng1; Chen, Nandi2,3,4; Qi, Yan1; Lyu, Meng2,3; Wu, Chaoyan5; Xie, Conghua1; Yu, Haijun1

2024

10.2147/IJN.S445805

INTERNATIONAL JOURNAL OF NANOMEDICINE   影响因子和分区

1178-2013

Background: Radiotherapy is an indispensable part of the multidisciplinary treatment of breast cancer (BC). Due to the potential for serious side effects from ionizing radiation in the treatment of breast cancer, which can adversely affect the patient's quality of life, the radiation dose is often limited. This limitation can result in an incomplete eradication of tumors.Methods: In this study, biomimetic copper single-atom catalysts (platelet cell membrane camouflaging, PC) were synthesized with the aim of improving the therapeutic outcomes of radiotherapy for BC. Following guidance to the tumor site facilitated by the platelet cell membrane coating, PC releases a copper single-atom nanozyme (SAzyme). This SAzyme enhances therapeutic effects by generating reactive oxygen species from H2O2 and concurrently inhibiting the self-repair mechanisms of cancer cells through the consumption of intracellular glutathione (GSH) within the tumor microenvironment. PC-augmented radiotherapy induces immunogenic cell death, which triggers an immune response to eradicate tumors.Results: With the excellent biocompatibility, PC exhibited precise tumor-targeting capabilities. Furthermore, when employed in conjunction with radiotherapy, PC showed impressive tumor elimination results through immunological activation. Remarkably, the tumor suppression rate achieved with PC-enhanced radiotherapy reached an impressive 93.6%.Conclusion: Therefore, PC presents an innovative approach for designing radiosensitizers with tumor-specific targeting capabilities, aiming to enhance the therapeutic impact of radiotherapy on BC.

platelet cell membrane single-atom nanozyme radiotherapy radioimmunotherapy breast cancer

SCI

英语

其他

National Natural Science Foundation of China[82073349] ; Technology & Innovation Commission of Shenzhen Municipality (Shenzhen, China)[JCYJ20190807145011340] ; Shenzhen High-tech Development Special Plan-Pingshan District Innovation Platform Project[29853M-KCJ-2023-002-04]

Science & Technology - Other Topics ; Pharmacology & Pharmacy

Nanoscience & Nanotechnology ; Pharmacology & Pharmacy

WOS:001148259900001

DOVE MEDICAL PRESS LTD

Web of Science

1.Wuhan Univ, Zhongnan Hosp, Hubei Prov Canc Clin Study Ctr, Dept Radiat & Med Oncol,Hubei Key Lab Tumor Biol B, Wuhan 430071, Hubei, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Dept Gastrointestinal Surg,C, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Geriatrics,Affiliated Hosp 1,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
4.Shenzhen Technol Univ, Anal & Testing Ctr, Shenzhen 518118, Peoples R China
5.Wuhan Univ, Zhongnan Hosp, Dept Integrated Tradit Chinese Med & Western Med, Wuhan 430071, Peoples R China

Chen, Cheng,Chen, Nandi,Qi, Yan,et al. Copper-Based Single-Atom Nanozyme System Mimicking Platelet Cells for Enhancing the Outcome of Radioimmunotherapy[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2024,19.

Chen, Cheng.,Chen, Nandi.,Qi, Yan.,Lyu, Meng.,Wu, Chaoyan.,...&Yu, Haijun.(2024).Copper-Based Single-Atom Nanozyme System Mimicking Platelet Cells for Enhancing the Outcome of Radioimmunotherapy.INTERNATIONAL JOURNAL OF NANOMEDICINE,19.

Chen, Cheng,et al."Copper-Based Single-Atom Nanozyme System Mimicking Platelet Cells for Enhancing the Outcome of Radioimmunotherapy".INTERNATIONAL JOURNAL OF NANOMEDICINE 19(2024).