Total synthesis of natural products containing bicyclo[n.2.2] ring systems

Hou, Bao-Long1,2,4,5; Liu, Junyang3,4,5; Qiao, Chuang4,5; Li, Chuang-Chuang4,5,6

2024-01-31

10.1016/j.tetlet.2023.154871

TETRAHEDRON LETTERS   影响因子和分区

0040-4039

1873-3581

Bridged bicyclo[m.n.2] ring systems (m >2, n >= 2) are important structural scaffolds, which are widely found in diverse families of natural products. Such natural products are attracting increasing research interests because of their intriguing architectural features and significant biological activities. However, the total synthesis of natural products containing a bridged bicyclo[m.n.2] ring system has proved to be very challenging because there are few efficient approaches to this unique structural motif. In this Minireview, seven representative types of natural products with bridged bicyclo[n.2.2] ring systems are discussed. For each example, we focus on the synthetic routes and highlight the methods and strategies used to prepare bridged bicyclo[n.2.2] ring systems. Lastly, a summary and outlook as well as a discussion of the key features of each strategy applied in the total syntheses are presented. This review demonstrates the creativity and diversity during the synthetic designs of bicyclo[m.n.2] ring systems.

Total synthesis Bicyclo[m.n.2] ring systems Bridged natural products Synthetic methods

SCI

英语

通讯

Guangdong Basic and Applied Basic Research Foundation["2020A1515110277","2021A1515010188"] ; National Natural Science Foundation of China["22225102","22371212"] ; Shenzhen Bay Laboratory[SZBL2021080601005] ; Research Projects of Universities of Guangdong Province["2021KCXTD024","2019KZDXM005"] ; Shenzhen Science and Technology Innovation Committee[JCYJ20210324104408023]

Chemistry

Chemistry, Organic

WOS:001141081400001

PERGAMON-ELSEVIER SCIENCE LTD

CHEMISTRY

Web of Science

1.Shaanxi Univ Chinese Med, Coconstruct Collaborat Innovat Ctr Chinese Med Res, Xianyang 712046, Shaanxi, Peoples R China
2.Shaanxi Univ Chinese Med, Educ Minist, Xianyang 712046, Shaanxi, Peoples R China
3.Wuyi Univ, Innovat Ctr Marine Biotechnol & Pharmaceut, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China
4.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China
5.Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalyt Chem, Shenzhen 518055, Peoples R China
6.Shenzhen Bay Lab, Shenzhen 518132, Peoples R China

Hou, Bao-Long,Liu, Junyang,Qiao, Chuang,et al. Total synthesis of natural products containing bicyclo[n.2.2] ring systems[J]. TETRAHEDRON LETTERS,2024,135.

Hou, Bao-Long,Liu, Junyang,Qiao, Chuang,&Li, Chuang-Chuang.(2024).Total synthesis of natural products containing bicyclo[n.2.2] ring systems.TETRAHEDRON LETTERS,135.

Hou, Bao-Long,et al."Total synthesis of natural products containing bicyclo[n.2.2] ring systems".TETRAHEDRON LETTERS 135(2024).