The correlation of lymphocytes with disease progression of COVID-19

Chu, Ming1,2; Zhao, Xiaobao2,3,4; Tang, Lu2,3,4,5; Zhang, Siwei2,3,4,5; Zhang, Shengkun1; Huang, Dongdong1; Wang, Fuxiang2,6; Wei, Lanlan2,3,4,5,7

2023-12-01

10.1097/MD.0000000000036244

MEDICINE   影响因子和分区

0025-7974

1536-5964

The aim of this study is to evaluate the potential of lymphocytes as biomarkers to predict the decline of coronavirus disease 2019 (COVID-19). Lymphocytes were counted in 164 moderate COVID-19 patients in Shenzhen, China. Among the moderate infected patients, 12.2% (20/164) progressed to severe cases after admission. Compared with the stable patients, the counts of lymphocytes, both total T lymphocytes and CD4+ T lymphocytes, in the severe patients, were lower. The aggravation of moderate infected patients was significantly associated with lymphocyte count (hazard ratio [HR] = 0.91; 95% confidence interval [CI]: 0.84-0.99), total T lymphocyte count (HR = 0.91; 95% CI: 0.84-0.99), and CD4+ T lymphocyte count (HR = 0.91; 95% CI: 0.85-0.98). Total T lymphocytes and CD4+ T lymphocytes could be important biomarkers to evaluate the risk of aggravation for moderate infected COVID-19 patients. The patients with low percentages of total T lymphocytes and CD4+ T lymphocytes need more attention.

COVID-19 prognosis T lymphocytes

SCI

英语

通讯

General & Internal Medicine

Medicine, General & Internal

WOS:001116697500045

LIPPINCOTT WILLIAMS & WILKINS

CLINICAL MEDICINE

Web of Science

1.Third Peoples Hosp Shenzhen, Dept Neurosurg, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Hosp 2, Shenzhen, Peoples R China
3.Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China
4.Shenzhen Third Peoples Hosp, Inst Hepatol, Shenzhen, Peoples R China
5.Harbin Med Univ, Dept Microbiol, Harbin, Peoples R China
6.Third Peoples Hosp Shenzhen, Dept Infect Dis, Shenzhen, Peoples R China
7.Southern Univ Sci & Technol, Hosp 2, Shenzhen 518000, Peoples R China

Chu, Ming,Zhao, Xiaobao,Tang, Lu,et al. The correlation of lymphocytes with disease progression of COVID-19[J]. MEDICINE,2023,102(48).

Chu, Ming.,Zhao, Xiaobao.,Tang, Lu.,Zhang, Siwei.,Zhang, Shengkun.,...&Wei, Lanlan.(2023).The correlation of lymphocytes with disease progression of COVID-19.MEDICINE,102(48).

Chu, Ming,et al."The correlation of lymphocytes with disease progression of COVID-19".MEDICINE 102.48(2023).