| 题名 | Epstein-Barr virus-based prognostic model in nodular sclerosis classic Hodgkin lymphoma |
| 作者 | |
| 通讯作者 | Laing, Yang; Yun, Jing-Ping; Huang, Yu-Hua |
| 发表日期 | 2024-01-19
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| DOI | |
| 发表期刊 | |
| EISSN | 2589-0042
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| 卷号 | 27期号:1 |
| 摘要 | The role of Epstein-Barr virus (EBV) in lymphoma cells of nodular sclerosis classic Hodgkin lymphoma (NScHL) is controversial. Our aim was to explore this and establish a clinically feasible model for risk stratification. We interrogated data from 542 consecutive subjects with NScHL receiving ABVD therapy and demonstrated EBV-infection in their lymphoma cells with EBV-encoded small RNAs (EBERs) in situ hybridization. Subjects were divided into training and validation datasets. As data from the training dataset suggested EBERs-positivity was the only independent prognostic factor for both progression-free survival (PFS) and overall survival (OS), we developed corresponding prognostic models based on it. Our models showed excellent performance in both training and validation cohort. These data indicate the close association of EBV infection and the outcomes of persons with NScHL receiving ABVD. Additionally, our newly developed models should help physicians estimate prognosis and select individualized therapy. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
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| 资助项目 | Ministry of Science and Technology of China[84000-51200002]
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| WOS研究方向 | Science & Technology - Other Topics
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| WOS类目 | Multidisciplinary Sciences
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| WOS记录号 | WOS:001139647200001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/789389 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Sun Yat Sen Univ Canc Ctr, Guangdong Prov Clin Res Ctr Canc, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou, Peoples R China 2.Sun Yat Sen Univ Canc Ctr, Dept Pathol, Guangzhou, Peoples R China 3.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Hematol, Shenzhen, Guangdong, Peoples R China 4.Dongguan Childrens Hosp, Dept Pathol, Dongguan, Guangdong, Peoples R China 5.Sun Yat Sen Univ Canc Ctr, Dept Med Oncol, Guangzhou, Peoples R China 6.Sun Yat Sen Univ Canc Ctr, Dept Hematol Oncol, Guangzhou, Peoples R China 7.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX USA 8.Imperial Coll Sci Technol & Med, Ctr Haematol, Dept Immunol & Inflammat, London, England |
| 推荐引用方式 GB/T 7714 |
Jiang, Chen,Huang, Li-Yun,Zhou, Ji-Hao,et al. Epstein-Barr virus-based prognostic model in nodular sclerosis classic Hodgkin lymphoma[J]. ISCIENCE,2024,27(1).
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| APA |
Jiang, Chen.,Huang, Li-Yun.,Zhou, Ji-Hao.,Li, Zhi-Min.,Wang, Yu.,...&Huang, Yu-Hua.(2024).Epstein-Barr virus-based prognostic model in nodular sclerosis classic Hodgkin lymphoma.ISCIENCE,27(1).
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| MLA |
Jiang, Chen,et al."Epstein-Barr virus-based prognostic model in nodular sclerosis classic Hodgkin lymphoma".ISCIENCE 27.1(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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