Exosomal circFAM63Bsuppresses bone regeneration of postmenopausal osteoporosis via regulating miR-578/HMGA2 axis

Li, Feng1; Zhao, Xiaodong1; Zhang, Yang1; Zhuang, Qingshan1; Wang, Song1; Fang, Xichi2; Xu, Tao2; Li, Xiaopeng1,3,4; Chen, Gaoyang2

2024-06-01

10.1002/jor.25776

JOURNAL OF ORTHOPAEDIC RESEARCH   影响因子和分区

0736-0266

1554-527X

Postmenopausal osteoporosis (PMOP) affects hundreds of millions of elderly women worldwide. The imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption is the key factor in the progression of PMOP. Recently, exosomal circular RNAs have been considered as critical regulators in physiological and pathological progress. However, their roles in PMOP still require further exploration. Herein, we identified that the expression of exosomal circFAM63B significantly increased in PMOP patients and is closely related to bone density. We further demonstrated that circFAM63B inhibits osteogenic differentiation of bone marrow stromal cells and bone formation in ovariectomy mice by using a combination of in vitro and in vivo experiment strategies. Mechanistically, circFAM63B promotes HMGA2 expression by inhibiting miR-578, thereby suppressing bone repair. Our study proved that exosomal circFAM63B suppresses the bone regeneration of PMOP by regulating the miR-578/HMGA2 axis, which may provide new insights into the pathogenesis and development of PMOP. Knocking down exosomal circFAM63B could be regarded as a new strategy for the treatment of PMOP.

bone formation circFAM63B HMGA2 miR-578 postmenopausal osteoporosis

SCI

英语

通讯

Natural Science Foundation of Shandong Province[ZR2020MH093] ; Medical and Health Science and Technology Development Project of Shandong Province[202004070241] ; Sanming Project of Medicine in Shenzhen[SZSM202111015] ; Shenzhen Key Medical Discipline Construction Fund[SZXK024] ; null[JCYJ20220530152812028]

Orthopedics

Orthopedics

WOS:001142139600001

WILEY

CLINICAL MEDICINE

Web of Science

1.Weifang Med Univ, Affiliated Hosp 1, Weifang Peoples Hosp, Dept Spine Surg, Weifang, Peoples R China
2.Southern Univ Sci & Technol, Dept Orthoped Surg, Div Hand & Foot & Microvasc Surg, Shenzhen Peoples Hosp,Affiliated Hosp 1,Shenzhen K, Shenzhen 518020, Peoples R China
3.Tianjin Med Univ, Clin Coll Orthoped, Tianjin, Peoples R China
4.Weifang Med Univ, Affiliated Hosp 1, Dept Spine Surg, Weifang 261000, Peoples R China

Li, Feng,Zhao, Xiaodong,Zhang, Yang,et al. Exosomal circFAM63Bsuppresses bone regeneration of postmenopausal osteoporosis via regulating miR-578/HMGA2 axis[J]. JOURNAL OF ORTHOPAEDIC RESEARCH,2024,42(6).

Li, Feng.,Zhao, Xiaodong.,Zhang, Yang.,Zhuang, Qingshan.,Wang, Song.,...&Chen, Gaoyang.(2024).Exosomal circFAM63Bsuppresses bone regeneration of postmenopausal osteoporosis via regulating miR-578/HMGA2 axis.JOURNAL OF ORTHOPAEDIC RESEARCH,42(6).

Li, Feng,et al."Exosomal circFAM63Bsuppresses bone regeneration of postmenopausal osteoporosis via regulating miR-578/HMGA2 axis".JOURNAL OF ORTHOPAEDIC RESEARCH 42.6(2024).