Antioxidant and anti-aging potential of collagen peptide conjugated with ionic liquid

Lu, Beibei1,2,3,4,5,6; Han, Shuqi7; Wang, Zhenyuan8; Xie, Lin5,6; Zhan, Jingbo8; Zhang, Jianglin1,2,3,4; Zhang, Jiaheng5,6

2024-01-15

10.1016/j.molliq.2023.123739

JOURNAL OF MOLECULAR LIQUIDS   影响因子和分区

0167-7322

1873-3166

Lactobionic acid-arginine (LAA) ionic liquid was prepared using an ion-exchange method. The LAA ionic liquid and five kinds of different molecular weights of collagen can self-assemble into spherical 5D LAA-Collagen peptides in solution. The 5D LAA-Collagen peptide has a small particle size, good stability, and biocompatibility, and can transdermally deliver collagen with different molecular weights to the epidermis and dermis through the skin. The activity and expression of IL-1 beta, MMP-1, and TNF-alpha decreased after adding 5D LAA-Collagen peptide. 5D LAA-Collagen peptide can inhibit MAPKs phosphorylation, activate the PI3K/AKT signaling pathway, increase the protein expression of Nrf2, and inhibit the high protein expression of Keapl to play an anti-aging role in multiple ways. The 5D LAA-Collagen peptide has a good antioxidant ability, can delay cell aging and death, and can reduce the length and number of facial wrinkles, fine facial lines, and texture to achieve an anti-wrinkle effect. Therefore, 5D LAA-Collagen peptide has potential applications in the field of cosmetics.

Ionic liquid Collagen peptide Transdermal delivery Antioxidant Anti-wrinkle

SCI

英语

通讯

National Natural Science Foundation of China["82073018","21703218"] ; Shenzhen Science and Technology Innovation Committee["JCYJ20180507183907224","KQTD2017080 9110344233"] ; Economic, Trade and Information Commission of Shenzhen Municipality through the Graphene Manufacture Innovation Center[201901161514] ; Guangdong Province Covid-19 Pandemic Control Research Fund[2020KZDZX1220] ; China Postdoctoral Science Foundation[2023M732379]

Chemistry ; Physics

Chemistry, Physical ; Physics, Atomic, Molecular & Chemical

WOS:001137952100001

ELSEVIER

CHEMISTRY

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Dermatol, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Natl Clin Res Ctr Skin Dis, Candidate Branch, Shenzhen 518020, Guangdong, Peoples R China
4.Dept Shenzhen Peoples Hosp, Geriatr Ctr, Shenzhen 518020, Guangdong, Peoples R China
5.Harbin Inst Technol Shenzhen, Sauvage Lab Smart Mat, Shenzhen 518055, Peoples R China
6.Harbin Inst Technol Shenzhen, Res Ctr Printed Flexible Elect, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China
7.Shanghai Boshe Biotechnol Co Ltd, Sch Mat Sci & Engn, Shanghai 201403, Peoples R China
8.Shenzhen Shinehigh Innovat Technol Co Ltd, Shenzhen 518055, Peoples R China

Lu, Beibei,Han, Shuqi,Wang, Zhenyuan,et al. Antioxidant and anti-aging potential of collagen peptide conjugated with ionic liquid[J]. JOURNAL OF MOLECULAR LIQUIDS,2024,394.

Lu, Beibei.,Han, Shuqi.,Wang, Zhenyuan.,Xie, Lin.,Zhan, Jingbo.,...&Zhang, Jiaheng.(2024).Antioxidant and anti-aging potential of collagen peptide conjugated with ionic liquid.JOURNAL OF MOLECULAR LIQUIDS,394.

Lu, Beibei,et al."Antioxidant and anti-aging potential of collagen peptide conjugated with ionic liquid".JOURNAL OF MOLECULAR LIQUIDS 394(2024).