Ventromedial hypothalamus relays chronic stress inputs and exerts bidirectional regulation on anxiety state and related sympathetic activity

Shao, Jie1,2; Chen, Yan3,4; Gao, Dashuang3; Liu, Yunhui3; Hu, Nan5; Yin, Lianghong2; Zhang, Xinzhou5; Yang, Fan3

2023-12-14

10.3389/fncel.2023.1281919

FRONTIERS IN CELLULAR NEUROSCIENCE   影响因子和分区

1662-5102

Chronic stress can induce negative emotion states, including anxiety and depression, leading to sympathetic overactivation and disturbed physiological homeostasis in peripheral tissues. While anxiety-related neural circuitry integrates chronic stress information and modulates sympathetic nervous system (SNS) activity, the critical nodes linking anxiety and sympathetic activity still need to be clarified. In our previous study, we demonstrated that the ventromedial hypothalamus (VMH) is involved in integrating chronic stress inputs and exerting influence on sympathetic activity. However, the underlying synaptic and electrophysiological mechanisms remain elusive. In this study, we combined in vitro electrophysiological recordings, behavioral tests, optogenetic manipulations, and SNS activity analyses to explore the role of VMH in linking anxiety emotion and peripheral SNS activity. Results showed that the VMH played an important role in bidirectionally regulating anxiety-like behavior and peripheral sympathetic excitation. Chronic stress enhanced excitatory inputs into VMH neurons by strengthening the connection with the paraventricular hypothalamus (PVN), hence promoting anxiety and sympathetic tone outflow, an important factor contributing to the development of metabolic imbalance in peripheral tissues and cardiovascular diseases.

chronic stress ventromedial hypothalamus anxiety sympathetic nervous system EPSC (excitatory postsynaptic current)

SCI

英语

通讯

National key R&D program of china[2023YFA1801200] ; National Natural Science Foundation of China, China["32300842","32271073","82072489"] ; China Postdoctoral Science Foundation, China[2023M732377] ; Guangdong Basic and Applied Basic Research Foundation, China[2020A1515111190] ; Shenzhen Fundamental Research Foundation, China["JCYJ20210324113001005","JCYJ20220818101600001"] ; Shenzhen Key Laboratory of Kidney Diseases, China[ZDSYS201504301616234] ; Shenzhen Governmental Sustainable Development Fund, China[KCXFZ20201221173612034] ; Shenzhen Medical Research Funding[C2301004] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties, China[SZGSP001]

Neurosciences & Neurology

Neurosciences

WOS:001131719000001

FRONTIERS MEDIA SA

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Nephrol, Shenzhen, Peoples R China
2.Jinan Univ, Affiliated Hosp 1, Guangzhou, Peoples R China
3.Chinese Acad Sci, Guangdong Prov Key Lab Brain Connectome & Behav, Brain Cognit & Brain Dis Inst,CAS Key Lab Brain Co, Shenzhen Inst Adv Technol,Shenzhen Hong Kong Inst, Shenzhen, Peoples R China
4.Beijing Sport Univ, Sch Sport Med & Rehabil, Beijing, Peoples R China
5.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Nephrol,Clin Med Coll 2, Shenzhen, Peoples R China

Shao, Jie,Chen, Yan,Gao, Dashuang,et al. Ventromedial hypothalamus relays chronic stress inputs and exerts bidirectional regulation on anxiety state and related sympathetic activity[J]. FRONTIERS IN CELLULAR NEUROSCIENCE,2023,17.

Shao, Jie.,Chen, Yan.,Gao, Dashuang.,Liu, Yunhui.,Hu, Nan.,...&Yang, Fan.(2023).Ventromedial hypothalamus relays chronic stress inputs and exerts bidirectional regulation on anxiety state and related sympathetic activity.FRONTIERS IN CELLULAR NEUROSCIENCE,17.

Shao, Jie,et al."Ventromedial hypothalamus relays chronic stress inputs and exerts bidirectional regulation on anxiety state and related sympathetic activity".FRONTIERS IN CELLULAR NEUROSCIENCE 17(2023).