Surface bioactivation of Polyetheretherketone (PEEK) by magnesium chondroitin sulfate (MgCS) as orthopedic implants for reconstruction of skeletal defects

Xu, Lei1; Li, Meixin1; Ma, Fenbo3; Zhang, Hongan1; Liang, Xiajun1; Cheng, Guoyun1; Li, Ying1; Ruiz-Ortega, L. I.6,7; Sun, Dawei1; Tang, Bin3,4,5; Qin, Chenghe1,2

2024-08-01

10.1016/j.ijbiomac.2024.133435

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES   影响因子和分区

0141-8130

1879-0003

Polyether-ether-ketone (PEEK) is clinically used as a bio-implant for the healing of skeletal defects. However, the osseointegration of clinical-sized bone grafts remains limited. In this study, surface-porous PEEK was created by using a sulfonation method and a metal-polysaccharide complex MgCS was introduced on the surface of sulfonated PEEK to form MgCS@SPEEK. The as-prepared MgCS@SPEEK was found to have a porous surface with good hydrophilicity and bioactivity. This was followed by an investigation into whether MgCS loaded onto sulfonated PEEK surfaces could promote osseointegration and angiogenesis. The in vitro results showed that MgCS@SPEEK had a positive effect on reducing the expression levels of inflammatory genes and promoting osteogenesis and angiogenesis-related genes expression levels. Furthermore, porous MgCS@SPEEK was implanted in critical-sized rat tibial defects for in vivo evaluation of osseointegration. The micro-computed tomography evaluation results revealed substantial bone formation at 4 and 8 weeks. Collectively, these findings indicate that MgCS@SPEEK could provide improved osseointegration and an attractive strategy for orthopaedic applications.

PEEK Surface modification Bone defects

SCI ; EI

英语

通讯

Funding of Science and Technology Projects in Guangzhou["202201020476","202201011015"] ; National Natural Science Foundation of China[82202689] ; National Key Research and Development Program of China[2019YFA0906004] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Shenzhen Science and Technology Innovation Committee["KCXFZ20211020174805009","JSGG20200225151916021"]

Biochemistry & Molecular Biology ; Chemistry ; Polymer Science

Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science

WOS:001264436900001

ELSEVIER

20242716607007

Computerized tomography ; Ethers ; Genes ; Magnesium compounds ; Sulfur compounds

Biological Materials and Tissue Engineering:461.2 ; Computer Applications:723.5 ; Organic Compounds:804.1

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Jinan Univ, Dept Orthopaed & Traumatol, Affiliated Guangdong Prov Gen Hosp 2, Guangzhou, Peoples R China
2.Nanfang Hosp, Dept Orthopaed, Div Orthopaed & Traumatol, Guangzhou, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen, Peoples R China
4.Guangdong Prov Key Lab Cell Microenvironm & Dis Re, Shenzhen, Peoples R China
5.Shenzhen Key Lab Cell Microenvironm, Shenzhen, Peoples R China
6.Columbia Univ, Dept Biol Sci, New York, NY 10027 USA
7.Univ Estatal Sonora UES, Ingn Biomed, Hermosillo, Sonora, Mexico

Xu, Lei,Li, Meixin,Ma, Fenbo,et al. Surface bioactivation of Polyetheretherketone (PEEK) by magnesium chondroitin sulfate (MgCS) as orthopedic implants for reconstruction of skeletal defects[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,274.

Xu, Lei.,Li, Meixin.,Ma, Fenbo.,Zhang, Hongan.,Liang, Xiajun.,...&Qin, Chenghe.(2024).Surface bioactivation of Polyetheretherketone (PEEK) by magnesium chondroitin sulfate (MgCS) as orthopedic implants for reconstruction of skeletal defects.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,274.

Xu, Lei,et al."Surface bioactivation of Polyetheretherketone (PEEK) by magnesium chondroitin sulfate (MgCS) as orthopedic implants for reconstruction of skeletal defects".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 274(2024).