Detection of minimal hepatic encephalopathy in patients with cirrhosis based on the Stroop-CN model (NCRCID-CHESS 2106): a prospective multicenter study

Li, Xiaoyan1,2; Liu, Shanghao3,4,5; Guo, Ying6; Zu, Hongmei7; Xiang, Huiling8; Yang, Shaoqi9; Zhang, Xiaoning2; Meng, Fanping2; Bianba, Yangzhen10; Li, Jie11; Liu, Fei12; Lei, Chuang13; Lv, Jiaojian14; Yang, Qiao-hua15; Fu, Wei16; Ye, Wei17; Chen, Jiafang18; Gao, Yanjing19; Wu, Caiyun20; Wang, Ningning21; Zheng, Qi22; Wang, Fang23; Yu, Jiali24; Wang, Jing25; Yang, Xiaoting26; Wang, Xiangmei27; Liu, Yayuan28; Zhao, Xuelan29; Wu, Chenxi30; Gou, Wei31; Bajaj, Jasmohan S.32; Wang, Fu-Sheng1,2; Fu, Junliang1,2; Qi, Xiaolong3,4,5

2024-08-01

10.1002/mco2.627

MEDCOMM   影响因子和分区

2688-2663

["Minimal hepatic encephalopathy (MHE) has a substantial impact on the clinical outcomes and quality of life (QOL) of patients with cirrhosis. However, timely diagnosis and intervention are challenging due to sophisticated diagnostic methods. In this study, 673 healthy controls and 905 patients with cirrhosis were screened, and 660 healthy controls and 757 patients with cirrhosis, divided into the test (292 patients) and validation (465 patients) cohort, were analyzed after screening. A diagnostic model of the Stroop test (Stroop-CN) was constructed by multivariate linear regression based on the results of healthy controls. The prevalence of MHE and the comparison results with psychometric hepatic encephalopathy score through the Stroop-CN model were stable in the test and validation cohorts. Moreover, the prevalence of MHE remained significantly higher in patients with worse disease conditions marked as high Child-Pugh grades and the Model for End-stage Liver Disease and Sodium (MELD-Na) scores in the test and validation cohort. The EuroQol 5-D questionnaire revealed that patients with MHE had a worse QOL than those without MHE both in the test and validation cohort. In conclusion, an easy and practical Stroop-CN model for MHE diagnosis based on the EncephalApp is established. It is found that a considerable number of Chinese patients with cirrhosis experience MHE, which significantly impacts their QOL.","The Stroop-CN model was developed based on health control results and was used to identify MHE patients among cirrhotic patients. This subset of MHE patients had significantly lower quality of life than non-MHE patients.image"]

cirrhosis minimal hepatic encephalopathy quality of life Stroop test

ESCI

英语

其他

Capital clinical diagnosis and treatment technology research and transformation application project[Z201100005520046] ; National Key R&D Program of China[2023YFC2308100] ; National Natural Science Foundation of China["82330060","92059202","92359304"] ; Tianjin Key Medical Specialty Construction Project[TJYXZDXK-034A] ; Tianjin Health Science and Technology Project[TJWJ2022XK029] ; Key Research andDevelopment Program of Jiangsu Province[BE2023767a] ; Fundamental Research Fund of Southeast University[3290002303A2] ; Changjiang Scholars Talent Cultivation Project of Zhongda Hospital of Southeast University[2023YJXYYRCPY03]

Research & Experimental Medicine

Medicine, Research & Experimental

WOS:001271000400001

WILEY

Web of Science

1.Med Sch Chinese PLA, Beijing, Peoples R China
2.Fifth Med Ctr Chinese PLA Gen Hosp, Natl Clin Res Ctr Infect Dis, Dept Infect Dis, Beijing, Peoples R China
3.Southeast Univ, Zhongda Hosp, Jiangsu Prov State Lab AI Imaging & Intervent Radi, Ctr Portal Hypertens,Dept Radiol,Med Sch,Nurturing, Nanjing, Peoples R China
4.Southeast Univ, Zhongda Hosp, Basic Med Res & Innovat Ctr, Minist Educ, Nanjing, Peoples R China
5.State Key Lab Digital Med Engn, Nanjing, Peoples R China
6.Third Peoples Hosp Taiyuan, Dept Hepatol, Taiyuan, Peoples R China
7.Fourth Peoples Hosp Qinghai Prov, Dept Gastroenterol, Xining, Peoples R China
8.Tianjin Third Cent Hosp, Inst Hepatobiliary Dis, Dept Gastroenterol & Hepatol, Tianjin Key Lab Extracorporeal Life Support Crit D, Tianjin, Peoples R China
9.Ningxia Med Univ, Dept Gastroenterol, Gen Hosp, Yinchuan, Peoples R China
10.Third Peoples Hosp Tibet Autonomous Reg, Dept Hepatol, Lhasa, Peoples R China
11.Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Infect Dis,Med Sch, Nanjing, Peoples R China
12.Cent South Univ, Xiangya Hosp, Dept Infect Dis, Hunan Key Lab Viral Hepatitis, Changsha, Peoples R China
13.First Peoples Hosp Changde City, Dept Infect Dis, Changde, Peoples R China
14.Lishui City Peoples Hosp, Dept Infect Dis, Lishui, Peoples R China
15.First Peoples Hosp Huaihua, Hepatol Dept, Infect Dis Ctr, Huaihua, Peoples R China
16.Shenyang 739 Hosp, Dept Hepatol, Shenyang, Peoples R China
17.Nanjing Univ Tradit Chinese Med, Liver Cirrhosis Treatment Ctr, Nanjing Hosp, Nanjing, Peoples R China
18.Datong City Fourth Peoples Hosp, Dept Gastroenterol, Datong, Peoples R China
19.Shandong Univ, Qilu Hosp, Dept Gastroenterol, Jinan, Peoples R China
20.Third People's Hosp Linfen City, Dept Hepatol, Linfen, Peoples R China
21.First Hosp China Med Univ, Dept Gastroenterol, Shenyang, Peoples R China
22.Fujian Med Univ, Affiliated Hosp 1, Hepatol Res Inst, Dept Hepatol, Fuzhou, Peoples R China
23.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Dept Hepatol,Natl Clin Res Ctr Infect Dis,Sch Med, Shenzhen, Peoples R China
24.Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian, Peoples R China
25.Second Affiliated Hosp, Dept Gastroenterol, Baotou Med Coll, Baotou, Peoples R China
26.Wuzhong Peoples Hosp, Dept Gastroenterol, Wuzhong, Peoples R China
27.Fujian Med Univ, Mengchao Hepatobiliary Hosp, Dept Severe Hepatol, Fuzhou, Peoples R China
28.Cent Hosp Dandong, Dept Gastroenterol, Dandong, Peoples R China
29.Chongqing Publ Hlth Med Ctr, Dept Gastroenterol Liver Dis, Chongqing, Peoples R China
30.Yiyang Fourth Peoples Hosp, Liver Dis Diag & Treatment Ctr, Yiyang, Peoples R China
31.Qingdao Sixth Peoples Hosp, Qingdao, Peoples R China
32.Virginia Commonwealth Univ & Cent Virginia Vet Hea, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23219 USA

Li, Xiaoyan,Liu, Shanghao,Guo, Ying,et al. Detection of minimal hepatic encephalopathy in patients with cirrhosis based on the Stroop-CN model (NCRCID-CHESS 2106): a prospective multicenter study[J]. MEDCOMM,2024,5(8).

Li, Xiaoyan.,Liu, Shanghao.,Guo, Ying.,Zu, Hongmei.,Xiang, Huiling.,...&Qi, Xiaolong.(2024).Detection of minimal hepatic encephalopathy in patients with cirrhosis based on the Stroop-CN model (NCRCID-CHESS 2106): a prospective multicenter study.MEDCOMM,5(8).

Li, Xiaoyan,et al."Detection of minimal hepatic encephalopathy in patients with cirrhosis based on the Stroop-CN model (NCRCID-CHESS 2106): a prospective multicenter study".MEDCOMM 5.8(2024).