Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives

Zang, Dongdong1; Yang, Xuemei2; Wang, Hao3,4; Li, Zhenxing2; Ma, Yanjun5; Liu, Jianxi5; Mei, Xi6; Li, Shupeng7; Feng, Jinxing1; Shi, Xin8,9; Tan, Zhen1,2

2024-12-01

10.1016/j.clinsp.2024.100435

CLINICS   影响因子和分区

1807-5932

1980-5322

Objective: This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects. Methods: Four HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds. Results: In the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day. In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group. Conclusion: The results of the forced swimming test, locomotor sensitization test, and conditioned location preference test showed that compounds C and D may have certain anti-depressant activity. However, HNK exerts a rapid and significant antidepressant effect within 1 week, but the duration is short.

Hydroxynorketamine and its Derivatives Forced Swimming Test Behavioral Sensitization Test Conditioned Place Preference Test Antidepressant

SCI

英语

其他

Sanming Project of Medicine in Shenzhen[SZSM202311027] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key specialties[SZXK035] ; Shenzhen Health Elite Talent Project[2021XKQ193] ; Sanming Project of Medicine in Shenzhen "Multidisciplinary epilepsy diagnosis and treatment team of Prof. Wang Yuping from Xuanwu Hospital Capital Medical University"[SZSM202003006] ; Basic research of Shenzhen Science and Technology Plan Project[JCYJ20220530155611026]

General & Internal Medicine

Medicine, General & Internal

WOS:001270378700001

ELSEVIER ESPANA

Web of Science

1.Shenzhen Childrens Hosp, Dept Neonatol, Shenzhen, Guangdong, Peoples R China
2.Shenzhen Univ, Clin Med Acad, Gen Hosp, Hlth Management Ctr, Shenzhen, Guangdong, Peoples R China
3.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Clin Med Coll 2,Affiliated Hosp 1,Dept Neurosurg, Shenzhen, Guangdong, Peoples R China
4.Guangdong Engn Technol Res Ctr Nervous Anat & Rela, Shenzhen, Guangdong, Peoples R China
5.Shenzhen Ruijian Biotechnol Co LTD, Shenzhen, Guangdong, Peoples R China
6.Zhuhai Pengkun Biomed Technol Co LTD, Zhuhai City, Guangdong, Peoples R China
7.Peking Univ, Sch Chem Biol & Biotechnol, State Key Lab Oncogen, Shenzhen, Guangdong, Peoples R China
8.Shenzhen Univ, Dept Neurosurg, Gen Hosp, Shenzhen, Guangdong, Peoples R China
9.Shenzhen Univ, Clin Med Acad Ctr, Shenzhen, Guangdong, Peoples R China

Zang, Dongdong,Yang, Xuemei,Wang, Hao,et al. Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives[J]. CLINICS,2024,79.

Zang, Dongdong.,Yang, Xuemei.,Wang, Hao.,Li, Zhenxing.,Ma, Yanjun.,...&Tan, Zhen.(2024).Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives.CLINICS,79.

Zang, Dongdong,et al."Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives".CLINICS 79(2024).