Phase separation as a new form of regulation in innate immunity

Wang, Lei1; Zhou, Wen2,3

2024-07-11

10.1016/j.molcel.2024.06.004

MOLECULAR CELL   影响因子和分区

1097-2765

1097-4164

Innate immunity is essential for the host against pathogens, cancer, and autoimmunity. The innate immune system encodes many sensor, adaptor, and effector proteins and relies on the assembly of higher-order signaling complexes to activate immune defense. Recent evidence demonstrates that many of the core complexes involved in innate immunity are organized as liquid-like condensates through a mechanism known as phase separation. Here, we discuss phase-separated condensates and their diverse functions. We compare the biochemical, structural, and mechanistic details of solid and liquid-like assemblies to explore the role of phase separation in innate immunity. We summarize the emerging evidence for the hypothesis that phase separation is a conserved mechanism that controls immune responses across the tree of life. The discovery of phase separation in innate immunity provides a new foundation to explain the rules that govern immune system activation and will enable the development of therapeutics to treat immune-related diseases properly.

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China (NSFC)[32270920] ; Shenzhen Talent Program[KQTD20210811090115021] ; Guangdong Innovative and Entrepreneurial Research Team Program[2021ZT09Y104] ; Shenzhen Science and Technology Program[ZDSYS20220402111000001]

Biochemistry & Molecular Biology ; Cell Biology

Biochemistry & Molecular Biology ; Cell Biology

WOS:001269661700001

CELL PRESS

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Southern Univ Sci & Technol, Sch Life Sci, Dept Syst Biol, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Sch Life Sci, Shenzhen Key Lab Biomol Assembling & Regulat, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Sch Life Sci, Dept Immunol & Microbiol, Shenzhen 518055, Peoples R China

Wang, Lei,Zhou, Wen. Phase separation as a new form of regulation in innate immunity[J]. MOLECULAR CELL,2024,84(13).

Wang, Lei,&Zhou, Wen.(2024).Phase separation as a new form of regulation in innate immunity.MOLECULAR CELL,84(13).

Wang, Lei,et al."Phase separation as a new form of regulation in innate immunity".MOLECULAR CELL 84.13(2024).