Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase

Huang, De-Liang1; Cai, Qin-Xian1; Zhou, Guang-De2; Yu, Hong3,4; Zhu, Zhi-Bin1; Peng, Jing-Han1; Chen, Jun1

2024-06-27

10.4254/wjh.v16.i6.920

WORLD JOURNAL OF HEPATOLOGY   影响因子和分区

1948-5182

BACKGROUND Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B (CHB) patients were not previously conducted. AIM To assess the liver histological changes in the indeterminate phase CHB patients using liver biopsy. METHODS The clinical and laboratory data of 1532 untreated CHB patients were collected, and all patients had least once liver biopsy from January 2015 to December 2021. The significant differences among different phases of CHB infection were compared with t-test, and the risk factors of significant liver histological changes were analyzed by the multivariate logistic regression analysis. RESULTS Among 1532 untreated CHB patients, 814 (53.13%) patients were in the indeterminate phase. Significant liver histological changes (defined as biopsy score >= G2 and/or >= S2) were found in 488/814 (59.95%) CHB patients in the indeterminate phase. Significant liver histological changes were significant differences among different age, platelets (PLTs), and alanine aminotransferase (ALT) subgroup in indeterminate patient. Multivariate logistic regression analysis indicated that age >= 40 years old [adjust odd risk (aOR), 1.44; 95% confidence interval (CI): 1.06-1.97; P = 0.02], PLTs <= 150 x 10(9)/L (aOR, 2.99; 95%CI: 1.85-4.83; P < 0.0001), and ALT >= upper limits of normal (aOR, 1.48; 95%CI: 1.08, 2.05, P = 0.0163) were independent risk factors for significant liver histological changes in CHB patients in the indeterminate phase. CONCLUSION Our results suggested that significant liver histological changes were not rare among the untreated CHB patients in indeterminate phase, and additional strategies are urgently required for the management of these patients.

Chronic hepatitis B Indeterminate phase Gray-zone Liver biopsy Pathological histology Risk factors

ESCI

英语

其他

Construction of Key Medical Disciplines in Shenzhen[SZXK076]

Gastroenterology & Hepatology

Gastroenterology & Hepatology

WOS:001265122300010

BAISHIDENG PUBLISHING GROUP INC

Web of Science

1.Third Peoples Hosp Shenzhen, Dept Liver Dis, 29 Shenzhen Long Gang Bulan Rd, Shenzhen 510000, Guangdong, Peoples R China
2.Capital Med Univ, Beijing Youan Hosp, Dept Pathol, Beijing, Peoples R China
3.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Dept Pathol, Shenzhen 518112, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Hosp 2, Shenzhen 518112, Guangdong, Peoples R China

Huang, De-Liang,Cai, Qin-Xian,Zhou, Guang-De,et al. Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase[J]. WORLD JOURNAL OF HEPATOLOGY,2024,16(6).

Huang, De-Liang.,Cai, Qin-Xian.,Zhou, Guang-De.,Yu, Hong.,Zhu, Zhi-Bin.,...&Chen, Jun.(2024).Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase.WORLD JOURNAL OF HEPATOLOGY,16(6).

Huang, De-Liang,et al."Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase".WORLD JOURNAL OF HEPATOLOGY 16.6(2024).