Pulmonary tuberculosis in two preterm infants conceived by in vitro fertilization

Wang, Yanrong; Yang, Jinrong; Liu, Yaping; Deng, Lijing; Pan, Liping

2024-07-01

10.1080/20469047.2024.2376396

PAEDIATRICS AND INTERNATIONAL CHILD HEALTH   影响因子和分区

2046-9047

2046-9055

The early diagnosis of tuberculosis (TB) in infants is challenging owing to the non-specific clinical manifestations in infancy, particularly preterm infants. Two cases in preterm infants are reported. Case 1, conceived by in vitro fertilization (IVF), was born at 27 + 1 weeks gestational age weighing 880 g. He presented on Day 85 with intermittent fever. Following a course of systemic broadspectrum antibiotics, he deteriorated, developing acute respiratory distress syndrome (ARDS). TB Xpert polymerase chain reaction (PCR) of the sputum obtained by laryngeal aspiration confirmed Mycobacterium TB (MTB) on Day 97. He responded well to anti-tuberculosis treatment. His mother had a fever and headache and was diagnosed with COVID-19 79 days after delivery. The fever persisted for nearly 10 days after empirical treatment. She was eventually diagnosed with miliary TB and tuberculous meningitis 92 days after delivery. Case 2 was conceived by IVF and born at 36 + 6 weeks gestation weighing 2430 g. She presented on Day 15 with intermittent fever and abdominal distention. Chest and abdominal radiography demonstrated severe diffuse inflammatory changes. She had received BCG vaccination, and there was no history of contact with active TB. TB PCR of the sputum obtained by laryngeal aspiration confirmed MTB on Day 19. The asymptomatic mother was subsequently diagnosed with pulmonary and genital TB. TB should be considered as a differential diagnosis in infants with unexpected respiratory distress and fever. Women evaluated for infertility should be routinely screened for TB before receiving assisted reproductive treatment, particularly where TB is prevalent.

Tuberculosis preterm infant mother in vitro fertilization

SCI

英语

第一 ; 通讯

Shenzhen High-level Hospital Construction Fund[G2022049]

Pediatrics

Pediatrics

WOS:001268837900001

TAYLOR & FRANCIS LTD

Web of Science

Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Dept Neonatol, Shenzhen, Guangdong, Peoples R China

Wang, Yanrong,Yang, Jinrong,Liu, Yaping,et al. Pulmonary tuberculosis in two preterm infants conceived by in vitro fertilization[J]. PAEDIATRICS AND INTERNATIONAL CHILD HEALTH,2024.

Wang, Yanrong,Yang, Jinrong,Liu, Yaping,Deng, Lijing,&Pan, Liping.(2024).Pulmonary tuberculosis in two preterm infants conceived by in vitro fertilization.PAEDIATRICS AND INTERNATIONAL CHILD HEALTH.

Wang, Yanrong,et al."Pulmonary tuberculosis in two preterm infants conceived by in vitro fertilization".PAEDIATRICS AND INTERNATIONAL CHILD HEALTH (2024).