中文版 | English
题名

In situ manufacture of hydrogel lubrication coating on damaged tissue to resist adhesion

作者
通讯作者Fan, Zengjie; Ma, Shuanhong; Zhou, Feng
发表日期
2024-07-17
DOI
发表期刊
EISSN
2666-3864
卷号5期号:7
摘要
The human body involves many soft interfaces with excellent hydration and lubrication properties to resist biological adhesion. The abdominal cavity, one of the most important parts of soft tissues, commonly generates severe wear and adhesion-related complication upon encountering lubrication failure between the internal organs of the abdominal cavity and the abdominal wall. Here, we report a method for the manufacture of UV-cured hydrogel lubrication coating on damaged cecum tissue. The hydrogel coating consists of methacrylated carboxymethyl chitosan (MA-CMC) and o- nitrobenzene-grafted hyaluronic acid (HA-NB). The coating not only exhibits fast curing time, good bonding strength, as well as matching mechanics with organs but also shows good lubricity and anti-fouling properties. The anti-adhesion performance of the coating is verified in a constructed rat cecum-abdominal wall postoperative adhesion model. The current concept of hydrogel lubrication coating may help accelerate the development and clinical application of soft anti-adhesion materials.
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英语
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资助项目
Strategic Priority Research Program of the Chinese Academy of Sciences[XDB 0470201] ; National Natural Science Foundation of China["22032006","52075522","52322506"] ; Outstanding Youth Fund of Gansu Province[21JR7RA095] ; West Light Foundation, Chinese Academy of Sciences[xbzg-zdsys-202211] ; Key Research Project of Shandong Provincial Natural Science Foundation[ZR2021ZD27]
WOS研究方向
Chemistry ; Energy & Fuels ; Materials Science ; Physics
WOS类目
Chemistry, Multidisciplinary ; Energy & Fuels ; Materials Science, Multidisciplinary ; Physics, Multidisciplinary
WOS记录号
WOS:001274011800001
出版者
来源库
Web of Science
引用统计
成果类型期刊论文
条目标识符http://sustech.caswiz.com/handle/2SGJ60CL/790031
专题工学院_机械与能源工程系
作者单位
1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Gansu, Peoples R China
2.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
3.Lanzhou Univ, Sch Stomatol, Key Lab Dent Maxillofacial Reconstruct & Biol Inte, Lanzhou 730000, Gansu, Peoples R China
4.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Guangdong, Peoples R China
5.Yantai Zhongke Res Inst Adv Mat & Green Chem Engn, Shandong Lab Adv Mat & Green Manufacture Yantai, Yantai 264006, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Li, Renjie,Hu, Cewen,Gao, Luyao,et al. In situ manufacture of hydrogel lubrication coating on damaged tissue to resist adhesion[J]. CELL REPORTS PHYSICAL SCIENCE,2024,5(7).
APA
Li, Renjie.,Hu, Cewen.,Gao, Luyao.,Zhang, Yunlei.,Zhang, Pei.,...&Zhou, Feng.(2024).In situ manufacture of hydrogel lubrication coating on damaged tissue to resist adhesion.CELL REPORTS PHYSICAL SCIENCE,5(7).
MLA
Li, Renjie,et al."In situ manufacture of hydrogel lubrication coating on damaged tissue to resist adhesion".CELL REPORTS PHYSICAL SCIENCE 5.7(2024).
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