Robust, scalable, and highly selective spirocyclic catalysts for industrial hydroformylation and isomerization-hydroformylation

Zong, Yan1; Zhang, Runtong2,3; Ma, Baode1,2,3; Peng, Jianghua1; Wu, Chao1; Zou, Xiaomei1; Qian, Yu1; Chen, Gen-Qiang1,4; Zhang, Xumu1

2024-07-17

10.1126/sciadv.ado9607

SCIENCE ADVANCES   影响因子和分区

2375-2548

Hydroformylation (HF) or isomerization-hydroformylation (ISO-HF) represents the most direct and practical route for producing aldehydes on an industrial scale. To resolve the issues of low activity, low linear/branched (l/b) ratio, and low stability in HF and ISO-HF, we herein reported a class of spirocyclic diphosphites. Notably, the ligand termed O-SDPhite afforded excellent catalytic activity and regioselectivity for the HF of various olefins. Excellent l/b ratio and an unprecedented turnover number of up to 17,620,000 were achieved. O-SDPhite was also found to be effective in the regioselective ISO-HF of the industrially related cheap and abundant C4 Raffinates to n-valeraldehyde produced on a multimillion-ton scale. The reaction with O-SDPhite, superior to that of benchmark Biphephos, was continuously operated for 41 days and afforded an average 38.6 l/b ratio (31 days and 14.7 l/b ratio for Biphephos).

SCI ; EI

英语

第一 ; 通讯

National Key Research and Development Program of China[2023YFA1507500] ; Shenzhen Science and Technology Innovation Committee["KQTD20150717103157174","JCYJ20210324104202007"] ; Stable Support Plan Program of Shenzhen Natural Science Fund[20200925161222002] ; Key-Area Research and Development Program of Guangdong Province[2020B010188001] ; Innovative Team of Universities in Guangdong Province[2020KCXTD016] ; National Natural Science Foundation of China[21991113] ; National Natural Science Foundation of China["21901107","22171129"] ; Guangdong Basic and Applied Basic Research Foundation[2022B1515020055] ; China Postdoctoral Science Foundation[2023M731516] ; Shenzhen Public Service Platform for Carbon Capture, Utilization and Storage (CCUS) Technology[XMHT20230108018]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:001272595300013

AMER ASSOC ADVANCEMENT SCIENCE

20243016756429

Catalyst activity ; Isomerization ; Isomers ; Regioselectivity

Chemical Reactions:802.2 ; Chemical Operations:802.3 ; Chemical Agents and Basic Industrial Chemicals:803 ; Chemical Products Generally:804

Web of Science

1.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China
2.Shenzhen Polytech Univ, Ctr Carbon Neutral Catalysis & Engn, Shenzhen 518055, Peoples R China
3.Shenzhen Polytech Univ, Inst Carbon Neutral Technol, Shenzhen 518055, Peoples R China
4.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China

Zong, Yan,Zhang, Runtong,Ma, Baode,et al. Robust, scalable, and highly selective spirocyclic catalysts for industrial hydroformylation and isomerization-hydroformylation[J]. SCIENCE ADVANCES,2024,10(29).

Zong, Yan.,Zhang, Runtong.,Ma, Baode.,Peng, Jianghua.,Wu, Chao.,...&Zhang, Xumu.(2024).Robust, scalable, and highly selective spirocyclic catalysts for industrial hydroformylation and isomerization-hydroformylation.SCIENCE ADVANCES,10(29).

Zong, Yan,et al."Robust, scalable, and highly selective spirocyclic catalysts for industrial hydroformylation and isomerization-hydroformylation".SCIENCE ADVANCES 10.29(2024).