CT-based deep learning radiomics biomarker for programmed cell death ligand 1 expression in non-small cell lung cancer

Xu, Ting1; Liu, Xiaowen1; Chen, Yaxi1; Wang, Shuxing1; Jiang, Changsi2; Gong, Jingshan2

2024-07-31

10.1186/s12880-024-01380-8

BMC MEDICAL IMAGING   影响因子和分区

1471-2342

BackgroundProgrammed cell death ligand 1 (PD-L1), as a reliable predictive biomarker, plays an important role in guiding immunotherapy of lung cancer. To investigate the value of CT-based deep learning radiomics signature to predict PD-L1 expression in non-small cell lung cancers(NSCLCs).Methods259 consecutive patients with pathological confirmed NSCLCs were retrospectively collected and divided into the training cohort and validation cohort according to the chronological order. The univariate and multivariate analyses were used to build the clinical model. Radiomics and deep learning features were extracted from preoperative non-contrast CT images. After feature selection, Radiomics score (Rad-score) and deep learning radiomics score (DLR-score) were calculated through a linear combination of the selected features and their coefficients. Predictive performance for PD-L1 expression was evaluated via the area under the curve (AUC) of receiver operating characteristic, the calibration curves, and the decision curve analysis.ResultsThe clinical model based on Cytokeratin 19 fragment and lobulated shape obtained an AUC of 0.767(95% CI: 0.673-0.860) in the training cohort and 0.604 (95% CI:0.477-0.731) in the validation cohort. 11 radiomics features and 15 deep learning features were selected by LASSO regression. AUCs of the Rad-score were 0.849 (95%CI: 0.783-0.914) and 0.717 (95%CI: 0.607-0.826) in the training cohort and validation cohort, respectively. AUCs of DLR-score were 0.938 (95%CI: 0.899-0.977) and 0.818(95%CI:0.727-0.910) in the training cohort and validation cohort, respectively. AUCs of the DLR-score were significantly higher than those of the Rad-score and the clinical model.ConclusionThe CT-based deep learning radiomics signature could achieve clinically acceptable predictive performance for PD-L1 expression, which showed potential to be a surrogate imaging biomarker or a complement of immunohistochemistry assessment.

Deep learning Non-small cell lung cancer Programmed cell death ligand 1 Radiomics Immune checkpoint inhibitors

SCI

英语

通讯

Radiology, Nuclear Medicine & Medical Imaging

Radiology, Nuclear Medicine & Medical Imaging

WOS:001282247700003

BMC

CLINICAL MEDICINE

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen 518020, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Dept Radiol,Shenzhen Peoples Hosp,Clin Med Coll 2, 1F,Bldg 4,1017 Dongmen North Rd, Shenzhen 518020, Peoples R China

Xu, Ting,Liu, Xiaowen,Chen, Yaxi,et al. CT-based deep learning radiomics biomarker for programmed cell death ligand 1 expression in non-small cell lung cancer[J]. BMC MEDICAL IMAGING,2024,24(1).

Xu, Ting,Liu, Xiaowen,Chen, Yaxi,Wang, Shuxing,Jiang, Changsi,&Gong, Jingshan.(2024).CT-based deep learning radiomics biomarker for programmed cell death ligand 1 expression in non-small cell lung cancer.BMC MEDICAL IMAGING,24(1).

Xu, Ting,et al."CT-based deep learning radiomics biomarker for programmed cell death ligand 1 expression in non-small cell lung cancer".BMC MEDICAL IMAGING 24.1(2024).