Hepatic macrophage niche: a bridge between HBV-mediated metabolic changes with intrahepatic inflammation

Wang, Jun1,2,3; Lu, Hongzhou1,2; Li, Qian1,2

2024-07-18

10.3389/fimmu.2024.1414594

FRONTIERS IN IMMUNOLOGY   影响因子和分区

1664-3224

Hepatitis B Virus (HBV) is a stealthy and insidious pathogen capable of inducing chronic necro-inflammatory liver disease and hepatocellular carcinoma (HCC), resulting in over one million deaths worldwide per year. The traditional understanding of Chronic Hepatitis B (CHB) progression has focused on the complex interplay among ongoing virus replication, aberrant immune responses, and liver pathogenesis. However, the dynamic progression and crucial factors involved in the transition from HBV infection to immune activation and intrahepatic inflammation remain elusive. Recent insights have illuminated HBV's exploitation of the sodium taurocholate co-transporting polypeptide (NTCP) and manipulation of the cholesterol transport system shared between macrophages and hepatocytes for viral entry. These discoveries deepen our understanding of HBV as a virus that hijacks hepatocyte metabolism. Moreover, hepatic niche macrophages exhibit significant phenotypic and functional diversity, zonal characteristics, and play essential roles, either in maintaining liver homeostasis or contributing to the pathogenesis of chronic liver diseases. Therefore, we underscore recent revelations concerning the importance of hepatic niche macrophages in the context of viral hepatitis. This review particularly emphasizes the significant role of HBV-induced metabolic changes in hepatic macrophages as a key factor in the transition from viral infection to immune activation, ultimately culminating in liver inflammation. These metabolic alterations in hepatic macrophages offer promising targets for therapeutic interventions and serve as valuable early warning indicators, shedding light on the disease progression.

HBV hepatic macrophage niches liver inflammation metabolism lipid metabolism (fatty acids)

SCI

英语

第一 ; 通讯

China's National Key RD Programs[2023YFC2306700] ; National Science Foundation of China[82301973] ; Chinesisch-Deutsches Mobilitats programm[M-0569] ; Basic and Applied Basic Research Fund of Guangdong Province: Regional Joint Fund-Youth Fund Project["2021A1515110831","2022A1515111163"] ; China Post-Doctoral Science Foundation[2022M721473] ; Shenzhen Third People's Hospital project["21250G1001","22240G1005"] ; Shenzhen Science and Technology Innovations Committee["JSGGZD20220822095200001","JCYJ20220530163406014"] ; Top Talent Support Program for young and middle-aged people of Wuxi Health Committee[BJ2023093] ; Research Projects of Wuxi Health Committee[M202203] ; Wuxi Science and Technology Fund Project[Y20222008]

Immunology

Immunology

WOS:001281200000001

FRONTIERS MEDIA SA

Web of Science

1.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Shenzhen, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 2, Shenzhen, Guangdong, Peoples R China
3.Jiangnan Univ, Peoples Hosp Wuxi 5, Clin Res Ctr, Wuxi, Jiangsu, Peoples R China

Wang, Jun,Lu, Hongzhou,Li, Qian. Hepatic macrophage niche: a bridge between HBV-mediated metabolic changes with intrahepatic inflammation[J]. FRONTIERS IN IMMUNOLOGY,2024,15.

Wang, Jun,Lu, Hongzhou,&Li, Qian.(2024).Hepatic macrophage niche: a bridge between HBV-mediated metabolic changes with intrahepatic inflammation.FRONTIERS IN IMMUNOLOGY,15.

Wang, Jun,et al."Hepatic macrophage niche: a bridge between HBV-mediated metabolic changes with intrahepatic inflammation".FRONTIERS IN IMMUNOLOGY 15(2024).