Reshaping tumor microenvironment by regulating local cytokines expression with a portable smart blue-light controlled device

Wang, Hui Rong1,2,3; Zhang, Yi4; Mo, Yue Jian2,3; Zhang, Zhan3; Chen, Rui3; Lu, Xi Bin3; Huang, Wei2,3

2024-07-29

10.1038/s42003-024-06566-y

COMMUNICATIONS BIOLOGY   影响因子和分区

2399-3642

["Cytokines have attracted sustained attention due to their multi-functional cellular response in immunotherapy. However, their application was limited to their short half-time, narrow therapeutic window, and undesired side effects. To address this issue, we developed a portable smart blue-light controlled (PSLC) device based on optogenetic technology. By combining this PSLC device with blue-light controlled gene modules, we successfully achieved the targeted regulation of cytokine expression within the tumor microenvironment. To alter the tumor microenvironment of solid tumors, pro-inflammatory cytokines were selected as blue-light controlled molecules. The results show that blue-light effectively regulates the expression of pro-inflammatory cytokines both in vitro and in vivo. This strategy leads to enhanced and activated tumor-infiltrating immune cells, which facilitated to overcome the immunosuppressive microenvironment, resulting in significant tumor shrinkage in tumor-bearing mice. Hence, our study offers a unique strategy for cytokine therapy and a convenient device for animal studies in optogenetic immunotherapy.","A study on optogenetics-based cytokine therapy suggests that the immunosuppressive tumor microenvironment can be reversed by beams of blue-light. This would enable control over the timing and location of cytokine expression at tumor sites."]

SCI

英语

通讯

National Natural Science Foundation of China (National Science Foundation of China)[2019YFA0906000] ; National Key R&D Program of China[31971181]

Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics

Biology ; Multidisciplinary Sciences

WOS:001280938100001

NATURE PORTFOLIO

Web of Science

1.Huanggang Normal Univ, LiShizhen Coll Tradit Chinese Med, Huanggang, Hubei, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Ctr Cell & Gene Circuit Design,CAS Key Lab Quantit, Shenzhen, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Sch Life Sci, Dept Biol, Shenzhen, Guangdong, Peoples R China
4.Brandeis Univ, Dept Biol, Waltham, MA USA

Wang, Hui Rong,Zhang, Yi,Mo, Yue Jian,et al. Reshaping tumor microenvironment by regulating local cytokines expression with a portable smart blue-light controlled device[J]. COMMUNICATIONS BIOLOGY,2024,7(1).

Wang, Hui Rong.,Zhang, Yi.,Mo, Yue Jian.,Zhang, Zhan.,Chen, Rui.,...&Huang, Wei.(2024).Reshaping tumor microenvironment by regulating local cytokines expression with a portable smart blue-light controlled device.COMMUNICATIONS BIOLOGY,7(1).

Wang, Hui Rong,et al."Reshaping tumor microenvironment by regulating local cytokines expression with a portable smart blue-light controlled device".COMMUNICATIONS BIOLOGY 7.1(2024).