Anti-inflammatory and antioxidant effects on skin based on supramolecular hyaluronic acid-ectoin

Lu, Beibei1,2,3,4,5,6; Zhao, Siran7; Zhang, Jichuan8; Zhan, Jingbo8; Zhang, Jianglin1,2,3,4; Liu, Zhe9; Zhang, Jiaheng5,6

2024-07-01

10.1039/d4tb00459k

JOURNAL OF MATERIALS CHEMISTRY B   影响因子和分区

2050-750X

2050-7518

["We addressed the damage caused by internal and external factors on the skin, as well as the aging phenomenon caused by delayed repair after damage. We prepared supramolecular hyaluronic acid-ectoin (HA-ECT) by combining theoretical calculations and experimental research, using intermolecular forces between hyaluronic acid and ectoin. This supramolecule has good stability, safety, and skin permeability and can penetrate the stratum corneum of the skin, reaching the epidermis and dermis of the skin. Compared with ectoin, the permeability of the supramolecule HA-ECT was 3.39-fold higher. Supramolecular HA-ECT can promote the proliferation of keratinocytes and fibroblasts, significantly increase the content of type collagen-I, reduce the expression of inflammatory factors in keratinocytes, and enhance skin hydration and repair effects. HA-ECT can reduce intracellular reactive oxygen species and inhibit the expression of matrix metalloproteinase-1 (reduced by 1.27-fold) to improve skin photoaging. Therefore, supramolecular HA-ECT has potential application in the field of cosmetics for skin antioxidants, anti-aging, and repair.","We prepared supramolecular hyaluronic acid-ectoin (HA-ECT) using intermolecular forces between hyaluronic acid and ectoin. Supramolecular HA-ECT has potential application in the field of cosmetics for skin antioxidants, anti-aging, and repair."]

SCI ; EI

英语

通讯

National Natural Science Foundation of China["82073018","21703218"] ; National Key R&D Program of China[2021YFC2103100] ; Shenzhen Science and Technology Innovation Committee["JCYJ20180507183907224","KQTD20170809110344233"] ; Economic, Trade and Information Commission of Shenzhen Municipality through the Graphene Manufacture Innovation Center[201901161514] ; China Postdoctoral Science Foundation[2023M732379]

Materials Science

Materials Science, Biomaterials

WOS:001281388400001

ROYAL SOC CHEMISTRY

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp Clin Med Coll 2, Dept Dermatol, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Natl Clin Res Ctr Skin Dis, Candidate Branch, Shenzhen 518020, Guangdong, Peoples R China
4.Dept Shenzhen Peoples Hosp Geriatr Ctr, Shenzhen 518020, Guangdong, Peoples R China
5.Harbin Inst Technol Shenzhen, Sauvage Lab Smart Mat, Shenzhen 518055, Peoples R China
6.Harbin Inst Technol Shenzhen, Res Ctr Printed Flexible Elect, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China
7.Natl Inst Metrol, Div Chem & Analyt Sci, Beijing 100029, Peoples R China
8.Shenzhen Shinehigh Innovat Technol Co Ltd, Shenzhen 518055, Peoples R China
9.Bloomage Biotech Co Ltd, Jinan 250104, Shandong, Peoples R China

Lu, Beibei,Zhao, Siran,Zhang, Jichuan,et al. Anti-inflammatory and antioxidant effects on skin based on supramolecular hyaluronic acid-ectoin[J]. JOURNAL OF MATERIALS CHEMISTRY B,2024.

Lu, Beibei.,Zhao, Siran.,Zhang, Jichuan.,Zhan, Jingbo.,Zhang, Jianglin.,...&Zhang, Jiaheng.(2024).Anti-inflammatory and antioxidant effects on skin based on supramolecular hyaluronic acid-ectoin.JOURNAL OF MATERIALS CHEMISTRY B.

Lu, Beibei,et al."Anti-inflammatory and antioxidant effects on skin based on supramolecular hyaluronic acid-ectoin".JOURNAL OF MATERIALS CHEMISTRY B (2024).