Bone-muscle crosstalk under physiological and pathological conditions

Dong, Yuechao1; Yuan, Hongyan2; Ma, Guixing1; Cao, Huiling1

2024-12-01

10.1007/s00018-024-05331-y

CELLULAR AND MOLECULAR LIFE SCIENCES   影响因子和分区

1420-682X

1420-9071

["Anatomically connected bones and muscles determine movement of the body. Forces exerted on muscles are then turned to bones to promote osteogenesis. The crosstalk between muscle and bone has been identified as mechanotransduction previously. In addition to the mechanical features, bones and muscles are also secretory organs which interact closely with one another through producing myokines and osteokines. Moreover, besides the mechanical features, other factors, such as nutrition metabolism, physiological rhythm, age, etc., also affect bone-muscle crosstalk. What's more, osteogenesis and myogenesis within motor system occur almost in parallel. Pathologically, defective muscles are always detected in bone associated diseases and induce the osteopenia, inflammation and abnormal bone metabolism, etc., through biomechanical or biochemical coupling. Hence, we summarize the study findings of bone-muscle crosstalk and propose potential strategies to improve the skeletal or muscular symptoms of certain diseases. Altogether, functional improvement of bones or muscles is beneficial to each other within motor system.","center dot Bone-muscle crosstalk is established by various osteokines and myokines.center dot Bone-muscle crosstalk is subjected to diseases not only defined in motor system.center dot MSCs secret exosomes rich in noncoding RNAs to function on muscles.center dot Bone metastasis of breast cancer is also harmful to muscles."]

Osteogenesis Myokines Muscle Chondrogenesis Obesity

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China["82372476","82350710800"] ; National Key Research and Development Program of China[2019YFA0906001] ; Guangdong Provincial Science and Technology Innovation Council[2017B030301018]

Biochemistry & Molecular Biology ; Cell Biology

Biochemistry & Molecular Biology ; Cell Biology

WOS:001281189700007

SPRINGER BASEL AG

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Southern Univ Sci & Technol, Dept Biochem,Sch Med, Shenzhen Key Lab Cell Microenvironm,Key Univ Lab M, Guangdong Prov Key Lab Cell Microenvironm & Dis Re, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Dept Mech & Aerosp Engn, Shenzhen Key Lab Soft Mech & Smart Mfg, Shenzhen 518055, Peoples R China

Dong, Yuechao,Yuan, Hongyan,Ma, Guixing,et al. Bone-muscle crosstalk under physiological and pathological conditions[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2024,81(1).

Dong, Yuechao,Yuan, Hongyan,Ma, Guixing,&Cao, Huiling.(2024).Bone-muscle crosstalk under physiological and pathological conditions.CELLULAR AND MOLECULAR LIFE SCIENCES,81(1).

Dong, Yuechao,et al."Bone-muscle crosstalk under physiological and pathological conditions".CELLULAR AND MOLECULAR LIFE SCIENCES 81.1(2024).