The effect of ambient temperature on lipid metabolism in children: From a prospective cohort study

Zhang，Di1,2,4,4; Kou，Wei3,4; Luo，Shunqing1; Chen，Jingyu1; An，Xizhou1; Fang，Shenying2; Liang，Xiaohua1,4

2024-11-15

10.1016/j.envres.2024.119692

Environmental Research   影响因子和分区

0013-9351

1096-0953

Background: Dyslipidemia is increasingly recognized as an essential risk factor for cardiovascular diseases. However, few studies illustrated the effects of ambient temperature exposure (TE) on lipid levels in children. The study aimed to examine the association between ambient TE and lipid levels in children. Methods: Based on a prospective cohort, a total of 2423 children (with 4466 lipids measure person-time) were collected from 2014 to 2019. The meteorological observation data and adjusted variables were collected. Mixed-effect models and generalized additive mixed model (GAMM) were applied to investigate the association between ambient TE and lipid levels. Results: A significant negative association was observed between TE and low-density lipoprotein cholesterol (LDL-C) or total cholesterol (TC) levels both in all children [LDL-C, β(95%CI) = −0.350(-0.434,-0.265), P < 0.001; TC, β(95%CI) = −0.274(-0.389,-0.160), P < 0.001] and by different sex group. However, no significant association was found in low-density lipoprotein cholesterol (HDL-C) or triglycerides (TG) levels. The estimated optimal ambient TEs for LDL-C were 18.273 °C and 18.024 °C for girls and boys, respectively. For TC, the optimal ambient TEs were 17.949 °C and 18.024 °C, respectively. With ambient TE decreased, the risk of dyslipidemia increased for both boys [OR = 0.032(0.006,0.179), P < 0.001] and girls [OR = 0.582(0.576,0.587), P < 0.001]. Conclusion: This study provided a comprehensive illustration about the associations between ambient TE and lipid levels in different sex and ages from a prospective cohort study. The findings will provide evidence for the government to prevent dyslipidemia in vulnerable children through regulating TE.

Ambient temperature Cohort study Dyslipidemia Lipid metabolism Lipomics analysis

SCI

英语

其他

ENVIRONMENT/ECOLOGY

2-s2.0-85200254783

Scopus

1.Department of Clinical Epidemiology and Biostatistics,Children's Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases,Chongqing,China
2.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,Guangdong,China
3.Department of Pediatric Otolaryngology Head and Neck Surgery,West China Second University Hospital,Sichuan University,Chengdu,China
4.

Zhang，Di,Kou，Wei,Luo，Shunqing,et al. The effect of ambient temperature on lipid metabolism in children: From a prospective cohort study[J]. Environmental Research,2024,261.

Zhang，Di.,Kou，Wei.,Luo，Shunqing.,Chen，Jingyu.,An，Xizhou.,...&Liang，Xiaohua.(2024).The effect of ambient temperature on lipid metabolism in children: From a prospective cohort study.Environmental Research,261.

Zhang，Di,et al."The effect of ambient temperature on lipid metabolism in children: From a prospective cohort study".Environmental Research 261(2024).