| 题名 | Cobalt-Catalyzed Enantioselective Reductive Arylation, Heteroarylation, and Alkenylation of Michael Acceptors via an Elementary Mechanism of 1,4-Addition |
| 作者 | |
| 通讯作者 | Zhou, Jianrong Steve |
| 发表日期 | 2024-07-24
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| DOI | |
| 发表期刊 | |
| ISSN | 0002-7863
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| EISSN | 1520-5126
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| 卷号 | 146页码:20477-20493 |
| 摘要 | Cobalt complexes with chiral quinox ligands effectively promote the enantioselective conjugate addition of enones using aryl, heteroaryl, and alkenyl halides and sulfonates. Additionally, a cobalt complex with a strongly donating diphosphine, BenzP*, successfully catalyzes the asymmetric reductive arylation and alkenylation of α,β-unsaturated amides. Both catalytic systems show broad scopes and tolerance of sensitive functional groups. Both reactions can be scaled up with low loadings of cobalt catalysts. Experimental results and density functional theory (DFT) calculations suggest a new mechanism of elementary 1,4-addition of aryl cobalt(I) complexes. © 2024 American Chemical Society. |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
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| 资助项目 | The authors acknowledge financial support from the National Natural Science Foundation of China (22271007), the State Key Laboratory of Chemical Oncogenomics, the Shenzhen Key Laboratory of Chemical Genomics, the Peking University Shenzhen Graduate School, and the Shenzhen Bay Laboratory for J.S.Z.; the National Natural Science Foundation of China (21933004) and the Shenzhen Bay Laboratory for Y.-D.W.; and the National Key R&D Program of China (2022YFA1505100), the National Natural Science Foundation of China (22201124), the Shenzhen Science and Technology Program (20231120100305001), and the Guangdong Provincial Key Laboratory of Catalysis (2020B121201002) for J.W.
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| 出版者 | |
| EI入藏号 | 20242916706088
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| EI主题词 | Amides
; Aromatic compounds
; Catalysis
; Cobalt compounds
; Density functional theory
; Enantioselectivity
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| EI分类号 | Physical Chemistry:801.4
; Chemical Reactions:802.2
; Chemical Agents and Basic Industrial Chemicals:803
; Chemical Products Generally:804
; Organic Compounds:804.1
; Probability Theory:922.1
; Atomic and Molecular Physics:931.3
; Quantum Theory; Quantum Mechanics:931.4
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| 来源库 | EV Compendex
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| 引用统计 |
被引频次[WOS]：2
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/794440 |
| 专题 | 理学院_化学系 南方科技大学 深圳格拉布斯研究院 |
| 作者单位 | 1.State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 2199 Lishui Road, Nanshan District, Shenzhen; 518055, China 2.Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen; 518055, China 3.Shenzhen Bay Laboratory, Gaoke Innovation Center, Guangqiao Road, Guangming District, Shenzhen; 518107, China 4.Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen; 518055, China |
| 推荐引用方式 GB/T 7714 |
Zhao, Mengxin,Xu, Wenqiang,Wu, Yun-Dong,et al. Cobalt-Catalyzed Enantioselective Reductive Arylation, Heteroarylation, and Alkenylation of Michael Acceptors via an Elementary Mechanism of 1,4-Addition[J]. Journal of the American Chemical Society,2024,146:20477-20493.
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| APA |
Zhao, Mengxin,Xu, Wenqiang,Wu, Yun-Dong,Yang, Xiuying,Wang, Jianchun,&Zhou, Jianrong Steve.(2024).Cobalt-Catalyzed Enantioselective Reductive Arylation, Heteroarylation, and Alkenylation of Michael Acceptors via an Elementary Mechanism of 1,4-Addition.Journal of the American Chemical Society,146,20477-20493.
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| MLA |
Zhao, Mengxin,et al."Cobalt-Catalyzed Enantioselective Reductive Arylation, Heteroarylation, and Alkenylation of Michael Acceptors via an Elementary Mechanism of 1,4-Addition".Journal of the American Chemical Society 146(2024):20477-20493.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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