Functional-Nanochannel-Based Artificial Postsynaptic Membrane for Neural Signal Transduction

Wang, Senyao1,2,3; Zhang, Wenyuan2; Wu, Minghui2; Wu, Yitian2; Xu, Guoheng2; Liu, Wenchao2; Mei, Tingting2; Chen, Lu1; Xiao, Kai2

2024-08-01

10.1002/adfm.202410597

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

["Biological-machine interface (BMI) devices represent a significant step toward adaptive and cognitive technologies. However, current BMI devices emphasize the analysis of electrophysiology and often overlook the chemical information of neurotransmitters in the process of signaling between neurons. To bridge this gap, a light-gated artificial postsynaptic membrane (APM) is introduced, capable of reading dopamine (DA) released from rat pheochromocytoma cells and regulate neural signal transmission. Like the biological postsynaptic membrane, the APM is a porous membrane functionalized by DA-specific aptamers and azobenzene (Azo) molecules in different regions. Azo molecules act as a light-responsive trigger that controls DA release, while DA-specific aptamers capture DA, which converts its concentration information into an ionic current signal. By light-enhanced responses to DA exocytosis from rat pheochromocytoma (PC12) cells, the APM confirms its ability to communicate with biological systems, which lays the foundation for developing biological-machine interaction systems with more advanced functionalities.","Here an artificial postsynaptic membrane (APM) is reported, featuring its ability to read dopamine (DA) levels modulated by light and regulate neural signal transmission. The APM is an integrated nanochannel membrane modified with aptamer-Azobenzene dual functionality. By light-enhanced responses to DA exocytosis from rat pheochromocytoma (PC12) cells, the APM confirms its ability to communicate with biological systems, which opens pathways for advanced biological-machine interaction systems. image"]

artificial synapse biological-machine interfaces dopamine recognition ionic devices nanofluidic systems

SCI ; EI

英语

通讯

National Key Technologies R&D Program of China[2023YFC2415900] ; National Natural Science Foundation of China["22275079","22304071"] ; Shenzhen Science and Innovation Committee[20220815164834003] ; Shenzhen Science and Technology Program["KQTD20221101093559017","JCYJ20230807093205011"] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Guangdong Basic and Applied Basic Research Foundation[2024A1515012600] ; High level of special funds[G03050K002] ; Post-doctoral Later-stage Foundation Project of Shenzhen Polytechnic[6023271015K] ; Shenzhen Polytechnic Research Fund[6023310022K]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:001286622500001

WILEY-V C H VERLAG GMBH

MATERIALS SCIENCE

Web of Science

1.Shenzhen Polytech Univ, Sch Mat & Environm Engn, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Inst Innovat Mat, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China
3.Tech Univ Munich, Munich Inst Biomed Engn, TUM Sch Computat Informat & Technol, Dept Elect Engn, Hans Piloty Str 1, D-85748 Garching, Germany

Wang, Senyao,Zhang, Wenyuan,Wu, Minghui,et al. Functional-Nanochannel-Based Artificial Postsynaptic Membrane for Neural Signal Transduction[J]. ADVANCED FUNCTIONAL MATERIALS,2024.

Wang, Senyao.,Zhang, Wenyuan.,Wu, Minghui.,Wu, Yitian.,Xu, Guoheng.,...&Xiao, Kai.(2024).Functional-Nanochannel-Based Artificial Postsynaptic Membrane for Neural Signal Transduction.ADVANCED FUNCTIONAL MATERIALS.

Wang, Senyao,et al."Functional-Nanochannel-Based Artificial Postsynaptic Membrane for Neural Signal Transduction".ADVANCED FUNCTIONAL MATERIALS (2024).