南方科技大学知识苑(SUSTech KC): Triborane (B<sub>3</sub>H<sub>7</sub>)-mediated regioselective substitution reactions of pyridine derivatives

题名	Triborane (B₃H₇)-mediated regioselective substitution reactions of pyridine derivatives
作者	Fan, Zi-Heng 1; Kang, Jia-Xin 1; Jia, Sihan 1; Pan, Qiao-Jing 1; Cao, Lei 1; Chen, Xi-Meng 1; Xu, Cong-Qiao2 ; Ma, Yan-Na 3; Chen, Xuenian 1,3
通讯作者	Ma, Yan-Na; Chen, Xuenian
发表日期	2024-07-01
DOI	10.1039/d4sc03109a
发表期刊	CHEMICAL SCIENCE 影响因子和分区
ISSN	2041-6520
EISSN	2041-6539
摘要	There exists an interplay between borane and a Lewis base in their adducts. However, studies on these adducts so far have mainly focused on the different reactions of B-H bonds with limited attention given to the influence of borane on the chemistry of the Lewis base, except for BF3 and BAr3. Herein, we have synthesized novel borane adducts with pyridine derivatives, PyB3H7, in which the coordination of B3H7 efficiently achieved the intra-molecular charge transfer. The strong B-N bond in these adducts resulted in the formation of stable dearomatic intermediates of pyridine derivatives, confirmed by H-1 and B-11 NMR spectroscopy, from which different reactions have transpired to realize C(sp(3))-H and C(sp(2))-H functionalization under mild conditions. The B3H7 pyridine derivatives are stable and do not dissociate or decompose during the reaction process. The high stability of the B-N bond makes this method a good option for boron-containing drugs with potential for use in boron neutron capture therapy (BNCT).
相关链接	[来源记录]
收录类别	SCI ; EI
语种	英语
学校署名	其他
资助项目	National Natural Science Foundation of China["22171246","22271256"]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:001287439500001
出版者	ROYAL SOC CHEMISTRY
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/803290
专题	理学院_化学系
作者单位	1.Henan Normal Univ, Sch Chem & Chem Engn, Henan Key Lab Boron Chem & Adv Mat, Xinxiang 453007, Henan, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China 3.Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Henan, Peoples R China
推荐引用方式 GB/T 7714	Fan, Zi-Heng,Kang, Jia-Xin,Jia, Sihan,et al. Triborane (B₃H₇)-mediated regioselective substitution reactions of pyridine derivatives[J]. CHEMICAL SCIENCE,2024.
APA	Fan, Zi-Heng.,Kang, Jia-Xin.,Jia, Sihan.,Pan, Qiao-Jing.,Cao, Lei.,...&Chen, Xuenian.(2024).Triborane (B₃H₇)-mediated regioselective substitution reactions of pyridine derivatives.CHEMICAL SCIENCE.
MLA	Fan, Zi-Heng,et al."Triborane (B₃H₇)-mediated regioselective substitution reactions of pyridine derivatives".CHEMICAL SCIENCE (2024).