Highly efficient synthesis of enantioenriched vicinal halohydrins via Ir-catalyzed asymmetric hydrogenation using dynamic kinetic resolution

He, Bin3; Chen, Gen-Qiang4,5; Zhang, Xumu1,2,6

2024-08-01

10.1039/d4cc02529f

CHEMICAL COMMUNICATIONS   影响因子和分区

1359-7345

1364-548X

A novel synthetic route was developed for the construction of chiral cis-vicinal halohydrins derivatives through Ir/f-phamidol-catalysed asymmetric hydrogenation of corresponding alpha-halogenated ketones with high yields (up to 99% yield), excellent diastereoselectivities (>20 : 1 dr), enantioselectivities (up to 99% ee), and high substrate catalyst ratio (S/C = 1000).

SCI ; EI

英语

通讯

National Key R&D Program of China[2021YFA1500200] ; Chemistry and Chemical Engineering Guangdong Laboratory["2011006","2132013"] ; Stable Support Plan Program of Shenzhen Natural Science Fund[20200925161222002] ; Key-Area Research and Development Program of Guangdong Province[2020B010188001] ; Innovative Team of Universities in Guangdong Province[2020KCXTD016] ; National Natural Science Foundation of China["21991113","22171129"] ; Shenzhen Science and Technology Innovation Committee[JCYJ20210324104202007] ; Guangdong Basic and Applied Basic Research Foundation[2022B1515020055]

Chemistry

Chemistry, Multidisciplinary

WOS:001293614800001

ROYAL SOC CHEMISTRY

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Med X Pingshan, Shenzhen 518000, Peoples R China
2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518000, Peoples R China
3.Inst Zhejiang Univ Quzhou, Quzhou 324000, Peoples R China
4.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China
5.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China
6.Chem & Chem Engn Guangdong Lab, Shantou 515031, Peoples R China

He, Bin,Chen, Gen-Qiang,Zhang, Xumu. Highly efficient synthesis of enantioenriched vicinal halohydrins via Ir-catalyzed asymmetric hydrogenation using dynamic kinetic resolution[J]. CHEMICAL COMMUNICATIONS,2024.

He, Bin,Chen, Gen-Qiang,&Zhang, Xumu.(2024).Highly efficient synthesis of enantioenriched vicinal halohydrins via Ir-catalyzed asymmetric hydrogenation using dynamic kinetic resolution.CHEMICAL COMMUNICATIONS.

He, Bin,et al."Highly efficient synthesis of enantioenriched vicinal halohydrins via Ir-catalyzed asymmetric hydrogenation using dynamic kinetic resolution".CHEMICAL COMMUNICATIONS (2024).