Association of metabolic syndrome severity with frailty progression among Chinese middle and old-aged adults: a longitudinal study

Zeng, Peng1,2,4; Li, Minjie1,2,3; Cao, Jixing6,7; Zeng, Long5; Jiang, Cheng1,2,4; Lin, Feng1,2,4

2024-08-16

10.1186/s12933-024-02379-9

CARDIOVASCULAR DIABETOLOGY   影响因子和分区

1475-2840

BackgroundThe binary diagnosis of Metabolic Syndrome(MetS) fails to accurately evaluate its severity, and the association between MetS severity and frailty progression remains inadequately elucidated. This study aims to clarify the relationship between the severity of MetS and the progression of frailty among the middle-aged and elderly population in China.MethodParticipants from the 2011-2018 China Health and Retirement Longitudinal Study(CHARLS) were included for a longitudinal analysis. The study employs a frailty index(FI) based on 32 health deficits to diagnose frailty and to assess FI trajectories. An age-sex-ethnicity-specific MetS scoring model (MetS score) was used to assess metabolic syndrome severity in Chinese adults. The Cumulative MetS score from 2012 to 2015 was calculated using the formula: (MetS score in wave 1 + MetS score in wave 3) / 2 x time(2015 - 2012). The association between MetS score, Cumulative MetS score, and the risk and trajectory of frailty were evaluated using Cox regression/logistic regression, and linear mixed models. Restricted Cubic Splines(RCS) models were utilized to detect potential non-linear associations.ResultsA higher MetS score was significantly associated with an increased risk of frailty(HR per 1 SD increase = 1.205; 95%CI: 1.14 to 1.273) and an accelerated FI trajectory(beta per 1 SD increase = 0.113 per year; 95%CI: 0.075 to 0.15 per year). Evaluating changes in MetS score using a Cumulative MetS score indicated that each 1 SD increase in the Cumulative MetS score increased the risk of frailty by 22.2%(OR = 1.222; 95%CI: 1.133 to 1.319) and accelerated the rate of increase in FI(beta = 0.098 per year; 95%CI: 0.058 to 0.138 per year). RCS model results demonstrated a dose-response curve relationship between MetS score and Cumulative MetS score with frailty risk. Stratified analysis showed consistency across subgroups. The interaction results indicate that in males and individuals under aged 60, MetS score may accelerate the increase in FI, a finding consistent across both models.ConclusionsOur findings underscore the positive correlation between the severity of MetS and frailty progression in the middle-aged and elderly, highlighting the urgent need for early identification of MetS and targeted interventions to reduce the risk of frailty.

Metabolic syndrome severity Frailty Longitudinal study Trajectory analysis CHARLS

SCI

英语

通讯

Shenzhen Key Medical Discipline Construction Fund[SZXK003] ; Sanming Project of Medicine in Shenzhen[SZSM201412012]

Cardiovascular System & Cardiology ; Endocrinology & Metabolism

Cardiac & Cardiovascular Systems ; Endocrinology & Metabolism

WOS:001292689300004

BMC

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Shenzhen Cardiovasc Minimally Invas Med Engn Techn, Dept Cardiol,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Shaanxi Univ Tradit Chinese Med, Affiliated Hosp 2, Xian 712000, Peoples R China
4.Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp, Inst Resp Dis,Southern Univ Sci & Technol,Clin Med, Shenzhen 518020, Guangdong, Peoples R China
5.Shangrao Peoples Hosp, Dept Cardiol, Shangrao 334000, Jiangxi, Peoples R China
6.Shenzhen Peoples Hosp, Dept Ophthalmol, Shenzhen 518020, Peoples R China
7.Jinan Univ, Affiliated Hosp 2, Shenzhen 518020, Peoples R China

Zeng, Peng,Li, Minjie,Cao, Jixing,et al. Association of metabolic syndrome severity with frailty progression among Chinese middle and old-aged adults: a longitudinal study[J]. CARDIOVASCULAR DIABETOLOGY,2024,23(1).

Zeng, Peng,Li, Minjie,Cao, Jixing,Zeng, Long,Jiang, Cheng,&Lin, Feng.(2024).Association of metabolic syndrome severity with frailty progression among Chinese middle and old-aged adults: a longitudinal study.CARDIOVASCULAR DIABETOLOGY,23(1).

Zeng, Peng,et al."Association of metabolic syndrome severity with frailty progression among Chinese middle and old-aged adults: a longitudinal study".CARDIOVASCULAR DIABETOLOGY 23.1(2024).