Restore Intestinal Barrier Integrity: An Approach for Inflammatory Bowel Disease Therapy

Kong, Chen1; Yang, Meifeng2; Yue, Ningning3; Zhang, Yuan4; Tian, Chengmei5,6; Wei, Daoru6,7; Shi, Ruiyue1; Yao, Jun1; Wang, Lisheng1,3,6; Li, Defeng1,3,6

2024

10.2147/JIR.S470520

JOURNAL OF INFLAMMATION RESEARCH   影响因子和分区

1178-7031

The intestinal barrier maintained by various types of columnar epithelial cells, plays a crucial role in regulating the interactions between the intestinal contents (such as the intestinal microbiota), the immune system, and other components. Dysfunction of the intestinal mucosa is a significant pathophysiological mechanism and clinical manifestation of inflammatory bowel disease (IBD). However, current therapies for IBD primarily focus on suppressing inflammation, and no disease-modifying treatments specifically target the epithelial barrier. Given the side effects associated with chronic immunotherapy, effective alternative therapies that promote mucosal healing are highly attractive. In this review, we examined the function of intestinal epithelial barrier function and the mechanisms of behind its disruption in IBD. We illustrated the complex process of intestinal mucosal healing and proposed therapeutic approaches to promote mucosal healing strategies in IBD. These included the application of stem cell transplantation and organ-like tissue engineering approaches to generate new intestinal tissue. Finally, we discussed potential strategies to restore the function of the intestinal barrier as a treatment for IBD.

inflammatory bowel disease intestinal barrier pathophysiology treatment

SCI

英语

通讯

Science and Technology Innovation Committee of Shenzhen["JCYJ20210324113802006","JCYJ 20210324113613035","JCYJ2022053015180024"]

Immunology

Immunology

WOS:001291945600001

DOVE MEDICAL PRESS LTD

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
2.Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen, Guangdong, Peoples R China
3.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, 1017,Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China
4.Huizhou Inst Occupat Dis Control & Prevent, Dept Med Adm, Huizhou, Guangdong, Peoples R China
5.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Emergency, Shenzhen, Guangdong, Peoples R China
6.Southern Univ Sci & Technol, Affiliated Hosp 1, 1017,Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China
7.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Rehabil, Shenzhen, Guangdong, Peoples R China

Kong, Chen,Yang, Meifeng,Yue, Ningning,et al. Restore Intestinal Barrier Integrity: An Approach for Inflammatory Bowel Disease Therapy[J]. JOURNAL OF INFLAMMATION RESEARCH,2024,17.

Kong, Chen.,Yang, Meifeng.,Yue, Ningning.,Zhang, Yuan.,Tian, Chengmei.,...&Li, Defeng.(2024).Restore Intestinal Barrier Integrity: An Approach for Inflammatory Bowel Disease Therapy.JOURNAL OF INFLAMMATION RESEARCH,17.

Kong, Chen,et al."Restore Intestinal Barrier Integrity: An Approach for Inflammatory Bowel Disease Therapy".JOURNAL OF INFLAMMATION RESEARCH 17(2024).