Assessment of LINC-PINT genetic polymorphisms and esophageal squamous cell carcinoma risk in the Hainan Han population

Tu, Ruisha1; Zhong, Dunjing2; Li, Ping3; Li, Yongyu2; Chen, Zhuang2; Hu, Feixiang1; Yuan, Guihong2; Chen, Zhaowei2; Yu, Shuyong1; Song, Jian4

2024-12-31

10.1080/07853890.2024.2397569

ANNALS OF MEDICINE   影响因子和分区

0785-3890

1365-2060

Objectives: Esophageal squamous cell carcinoma (ESCC) is a malignant tumor with high incidence and mortality rates worldwide. This study aimed to investigate the correlation between LINC-PINT polymorphisms and ESCC risk in the Hainan Han population. Methods: A total of 391 patients with ESCC and 452 healthy controls were enrolled to evaluate the effect of LINC-PINT SNPs (single nucleotide polymorphisms) on ESCC susceptibility. Associations were evaluated by calculating odds ratios (OR) and 95% confidence intervals (CIs). Multifactor dimensionality reduction analysis was performed to explore the association between SNP-SNP interactions and ESCC susceptibility. We further determined the correlation between clinical indicators and SNP in patients with ESCC. Results: Our study showed that rs157916 (OR 0.63, p = 0.011) and rs157928 (OR 0.80, p = 0.021) were associated with a decreased risk of ESCC. Stratified analysis indicated that rs157916 could decrease the risk of ESCC in people aged >64 years, in males, and non-drinkers (OR 0.58, p = 0.042; OR 0.58, p = 0.010; OR 0.62, p = 0.025, respectively). Rs16873842 was related to a decreased risk of ESCC in males (OR 0.70, p = 0.015). Rs7801029 was associated with ESCC risk in females (OR 0.39, p = 0.033) and non-drinkers (OR 0.68, p = 0.040). Rs7781295 decreased the ESCC risk in smokers (OR 0.58, p = 0.046) and drinkers (OR 0.58, p = 0.046). In addition, rs157928 played a protective role in ESCC risk in females (OR 0.39, p = 0.033) and non-smokers (OR 0.32, p = 0.006). Additionally, the best predictive model for ESCC was a combination of rs157916, rs16873842, rs7801029, rs7781295, rs28662387, and rs157928. Conclusion: Our study revealed that LINC-PINT polymorphisms were associated with ESCC risk.

Esophageal squamous cell carcinoma LINC-PINT genetic polymorphisms risk

SCI

英语

通讯

Hainan Provincial Major Science and Technology Project[ZDKJ202005] ; Innovation Platform for Academinicians of Hainan Province[YSPTZX202029]

General & Internal Medicine

Medicine, General & Internal

WOS:001303830800001

TAYLOR & FRANCIS LTD

CLINICAL MEDICINE

Web of Science

1.Hainan Canc Hosp, Dept Gastrointestinal Surg, Haikou, Hainan, Peoples R China
2.Hainan Canc Hosp, Dept Gastroenterol, Haikou, Hainan, Peoples R China
3.Hainan Canc Hosp, Dept Digest Endoscopy Ctr, Haikou, Hainan, Peoples R China
4.Southern Univ Sci & Technol Hosp, Dept Gastroenterol, Shenzhen, Peoples R China

Tu, Ruisha,Zhong, Dunjing,Li, Ping,et al. Assessment of LINC-PINT genetic polymorphisms and esophageal squamous cell carcinoma risk in the Hainan Han population[J]. ANNALS OF MEDICINE,2024,56(1).

Tu, Ruisha.,Zhong, Dunjing.,Li, Ping.,Li, Yongyu.,Chen, Zhuang.,...&Song, Jian.(2024).Assessment of LINC-PINT genetic polymorphisms and esophageal squamous cell carcinoma risk in the Hainan Han population.ANNALS OF MEDICINE,56(1).

Tu, Ruisha,et al."Assessment of LINC-PINT genetic polymorphisms and esophageal squamous cell carcinoma risk in the Hainan Han population".ANNALS OF MEDICINE 56.1(2024).