南方科技大学知识苑(SUSTech KC): Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells

题名	Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells
作者	Ding, Zhen ; Ma, Guixing ; Zhou, Bo ; Cheng, Siyuan; Tang, Wanze; Han, Yingying ; Chen, Litong; Pang, Wei; Chen, Yangshan; Yang, Dazhi; Cao, Huiling
通讯作者	Ma, Guixing; Cao, Huiling
发表日期	2024-08-20
DOI	10.1016/j.xcrm.2024.101665
发表期刊	CELL REPORTS MEDICINE 影响因子和分区
ISSN	2666-3791
卷号	5 期号:8
摘要	Mesenchymal stromal cell (MSC) senescence is a key factor in skeletal aging, affecting the potential of MSC applications. Identifying targets to prevent MSC and skeletal senescence is crucial. Here, we report increased miR-29 expression in bone tissues of aged mice, osteoporotic patients, and senescent MSCs. Genetic overexpression of miR-29 in Prx1-positive MSCs significantly accelerates skeletal senescence, reducing cortical bone thickness and trabecular bone mass, while increasing femur cross-sectional area, bone marrow adiposity, p53, and senescence-associated secretory phenotype (SASP) levels. Mechanistically, miR-29 promotes senescence by upregulating p53 via targeting Kindlin-2 mRNA. miR-29 knockdown in BMSCs impedes skeletal senescence, enhances bone mass, and accelerates calvarial defect regeneration, also reducing lipopolysaccharide (LPS)-induced organ injuries and mortality. Thus, our findings underscore miR-29 as a promising therapeutic target for senescence-related skeletal diseases and acute inflammation-induced organ damage.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Natural Science Foundation of China["82372476","82350710800"] ; National Key Research and Development Program of China[2019YFA0906001] ; Guangdong Provincial Science and Technology Innovation Council[2017B030301018]
WOS研究方向	Cell Biology ; Research & Experimental Medicine
WOS类目	Cell Biology ; Medicine, Research & Experimental
WOS记录号	WOS:001299209500001
出版者	CELL PRESS
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/805081
专题	南方科技大学医学院_生物化学系南方科技大学医学院
作者单位	Southern Univ Sci & Technol, Key Univ Lab Metab & Hlth Guangdong, Guangdong Prov Key Lab Cell Microenvironm & Dis Re, Dept Biochem,Sch Med, Shenzhen 518055, Peoples R China
第一作者单位	生物化学系; 南方科技大学医学院
通讯作者单位	生物化学系; 南方科技大学医学院
第一作者的第一单位	生物化学系; 南方科技大学医学院
推荐引用方式 GB/T 7714	Ding, Zhen,Ma, Guixing,Zhou, Bo,et al. Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells[J]. CELL REPORTS MEDICINE,2024,5(8).
APA	Ding, Zhen.,Ma, Guixing.,Zhou, Bo.,Cheng, Siyuan.,Tang, Wanze.,...&Cao, Huiling.(2024).Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells.CELL REPORTS MEDICINE,5(8).
MLA	Ding, Zhen,et al."Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells".CELL REPORTS MEDICINE 5.8(2024).