南方科技大学知识苑(SUSTech KC): Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging

题名	Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging
作者	Loh, Kang Yong 1,2,3; Li, Lei S.4,5; Fan, Jingyue 6; Goh, Yi Yiing 6,7; Liew, Weng Heng 1; Davis, Samuel 4; Zhang, Yide 4; Li, Kai1,8 ; Liu, Jie 9; Liang, Liangliang 6; Feng, Minjun 10; Yang, Ming 11; Zhang, Hang 11; Ma, Ping’an 12; Feng, Guangxue 13; Mu, Zhao 10; Gao, Weibo 10,14; Sum, Tze Chien 10; Liu, Bin 13; Lin, Jun 12; Yao, Kui 1; Wang, Lihong V.4; Liu, Xiaogang 1,6,15
通讯作者	Wang, Lihong V.; Liu, Xiaogang
发表日期	2024-12
DOI	10.1038/s43246-024-00605-1
发表期刊	Communications Materials 影响因子和分区
EISSN	2662-4443
卷号	5 期号:1
摘要	Photoacoustic tomography offers a powerful tool to visualize biologically relevant molecules and understand processes within living systems at high resolution in deep tissue, facilitated by the conversion of incident photons into low-scattering acoustic waves through non-radiative relaxation. Although current endogenous and exogenous photoacoustic contrast agents effectively enable molecular imaging within deep tissues, their broad absorption spectra in the visible to near-infrared (NIR) range limit photoacoustic multiplexed imaging. Here, we exploit the distinct ultrasharp NIR absorption peaks of lanthanides to engineer a series of NIR photoacoustic nanocrystals. This engineering involves precise host and dopant material composition, yielding nanocrystals with sharply peaked photoacoustic absorption spectra (~3.2 nm width) and a ~10-fold enhancement in NIR optical absorption for efficient deep tissue imaging. By combining photoacoustic tomography with these engineered nanocrystals, we demonstrate photoacoustic multiplexed differential imaging with substantially decreased background signals and enhanced precision and contrast. © The Author(s) 2024.
相关链接	[Scopus记录]
收录类别	EI ; ESCI
语种	英语
学校署名	其他
资助项目	We are very grateful to Renzhe Bi and Xiuting Li for their assistance in the initial stages of testing our nanocrystals in PA experiments. We also like to thank Melgious Ang for his assistance in conducting cellular toxicity studies on the nanocrystals. We also like to express our gratitude to Ding Ding for provided technical insights and guidance on experimental interpretation. This work is supported by National Research Foundation, Prime Minister’s Office, Singapore under its Competitive Research Program (Award No. NRF-CRP23-2019-0002) and under its NRF Investigatorship Programme (Award No. NRF-NRFI05-2019-0003), the RIE2025 Manufacturing, Trade and Connectivity (MTC) Programmatic Fund (Award No. M21J9b0085), and National Institutes of Health, United States, grants U01 NS099717 (BRAIN Initiative) and R01 EB028277A, the internal fund F10000205 from Rice University, the Basic Science Center Program for Ordered Energy Conversion of the National Natural Science Foundation of China (No. 51888103), National Natural Science Foundation of China (51606192) and the CAS Pioneer Hundred Talents Program. Partial supports by A*STAR, Singapore, RIE2020 Advanced Manufacturing and Engineering (AME) Programmatic Fund (Grant No. A20G9b0135) are acknowledged.
出版者	Springer Nature
EI入藏号	20243416921448
EI主题词	Infrared absorption ; Molecular imaging ; Photoacoustic effect ; Tissue ; Tissue engineering
EI分类号	:101.1 ; :101.1.1 ; :101.3 ; :1301.4.1 ; Electromagnetic Waves in Different Media:711.1 ; :741.1/Optics ; Imaging Techniques:746 ; Acoustic Waves:751.1 ; Nanotechnology:761
Scopus记录号	2-s2.0-85201701055
来源库	EV Compendex
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/807017
专题	工学院_生物医学工程系南方科技大学
作者单位	1.Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore 2.Department of Chemistry, Stanford University, Stanford; CA, United States 3.Sarafan ChEM-H, Stanford University, Stanford; CA, United States 4.Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena; CA, United States 5.Department of Electrical and Computer Engineering, Rice University, Houston; TX, United States 6.Department of Chemistry, National University of Singapore, Singapore, Singapore 7.NUS Graduate School, National University of Singapore, Singapore, Singapore 8.Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China 9.Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), Nanjing Tech University, Nanjing, China 10.Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore 11.Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing, China 12.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China 13.Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore 14.The Photonics Institute and Centre for Disruptive Photonic Technologies, Nanyang Technological University, Singapore, Singapore 15.Nanomedicine Translational Research Programme, Centre for NanoMedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
推荐引用方式 GB/T 7714	Loh, Kang Yong,Li, Lei S.,Fan, Jingyue,et al. Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging[J]. Communications Materials,2024,5(1).
APA	Loh, Kang Yong.,Li, Lei S..,Fan, Jingyue.,Goh, Yi Yiing.,Liew, Weng Heng.,...&Liu, Xiaogang.(2024).Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging.Communications Materials,5(1).
MLA	Loh, Kang Yong,et al."Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging".Communications Materials 5.1(2024).