Epidermal secretion-purified biosensing patch with hydrogel sebum filtering membrane and unidirectional flow microfluidic channels

Wang，Yuqi; Zhang，Ziyu; Shi，Yuqing; Yu，Xiong; Zhang，Xinyi; Ma，Xiaohao; Su，Junjie; Ding，Ruochen; Lin，Yuanjing

2025-02-01

10.1016/j.biomaterials.2024.122810

Biomaterials   影响因子和分区

0142-9612

1878-5905

The development of biosensing electronics for real-time sweat analysis has attracted increasing research interest due to their promising applications for non-invasive health monitoring. However, one of the critical challenges lies in the sebum interference that largely limits the sensing reliability in practical scenarios. Herein, we report a flexible epidermal secretion-purified biosensing patch with a hydrogel filtering membrane that can effectively eliminate the impact of sebum and sebum-soluble substances. The as-prepared sebum filtering membranes feature a dual-layer sebum-resistant structure based on the poly(hydroxyethyl methacrylate) hydrogel functionalized with nano-brush structured poly(sulfobetaine) to eliminate interferences and provide self-cleaning capability. Furthermore, the unidirectional flow microfluidic channels design based on the Tesla valve was incorporated into the biosensing patch to prevent external sebum contamination and allow effective sweat refreshing for reliable sensing. By seamlessly combining these components, the epidermal secretion-purified biosensing patch enables continuous monitoring of sweat uric acid, pH, and sodium ions with significantly improved accuracy of up to 12 %. The proposed strategy for enhanced sweat sensing reliability without sebum interference shows desirable compatibility for different types of biosensors and would inspire the advances of flexible and wearable devices for non-invasive healthcare.

Biosensors Microfluidic design Sebum filtering Sweat analysis Tesla valve

英语

第一 ; 通讯

MATERIALS SCIENCE

2-s2.0-85202997455

Scopus

School of Microelectronics,Southern University of Science and Technology,Shenzhen,518055,China

Wang，Yuqi,Zhang，Ziyu,Shi，Yuqing,et al. Epidermal secretion-purified biosensing patch with hydrogel sebum filtering membrane and unidirectional flow microfluidic channels[J]. Biomaterials,2025,313.

Wang，Yuqi.,Zhang，Ziyu.,Shi，Yuqing.,Yu，Xiong.,Zhang，Xinyi.,...&Lin，Yuanjing.(2025).Epidermal secretion-purified biosensing patch with hydrogel sebum filtering membrane and unidirectional flow microfluidic channels.Biomaterials,313.

Wang，Yuqi,et al."Epidermal secretion-purified biosensing patch with hydrogel sebum filtering membrane and unidirectional flow microfluidic channels".Biomaterials 313(2025).