10-year trajectory of Life’s Essential 8 and incident hypertension: a community-based cohort study

Zhong，Jiwen1; Jiang，Jinguo2; Guo，Liang3,4; Liu，Yang5; Wu，Shouling7; Peng，Xinyi8; Chen，Shuohua7; Qin，Xueying5,6; Dong，Shaohong9; Huang，Ruijun1; Zheng，Wei1

2024-12-01

10.1186/s12944-024-02257-z

Lipids in Health and Disease   影响因子和分区

1476-511X

Background: The health effects of Life’s Essential 8 (LE8) on chronic diseases have been disclosed, but its association with hypertension remains unknown. The current study aimed to explore the potential link between 10-year LE8 trajectory and the incidence of hypertension. Methods: LE8 was constructed from four behaviors and four metabolic factors, ranging from 0 to 100. Latent mixture models were used to identify trajectories of LE8 scores during 2006 to 2016. Incident hypertension was diagnosed based on self-reported clinical diagnoses and physical examinations from 2016 to 2020. Cox models were employed to assess the association of LE8 trajectories with hypertension. In addition to incorporating the mean hs-CRP levels from 2006 to 2016, age, sex, monthly income, educational level, and occupation at recruitment were adjusted for as confounding factors. Results: 7500 participants aged 40.28 ± 10.35 years were included in the study, of whom 2907 (38.76%) were women. Five LE8 trajectory patterns were identified. After around four-year follow-up, 667 hypertension events were observed. Compared to the Low-Stable trajectory, the hazard ratios and 95% confidence intervals for the Moderate-Increasing, Moderate-Decreasing, Moderate-Stable, and High-Stable trajectories were 0.51 (0.40, 0.65), 0.81 (0.64, 1.02), 0.45 (0.36, 0.58), 0.23 (0.16, 0.33), respectively. The risk of incident hypertension decreased as participants improved their LE8 status. The robustness of the primary results was confirmed through several sensitivity analyses. Conclusions: LE8 trajectories were associated with the incident hypertension. People who improved their LE8 scores over time experienced a decreased risk of hypertension, even if they started with lower LE8 scores initially.

Hypertension Life’s essential 8 Trajectory analysis

SCI

英语

其他

2-s2.0-85202925411

Scopus

1.Department of Critical Care Medicine,Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University),Zhuhai,Guangdong,51900,China
2.Department of Clinical Epidemiology,Shengjing Hospital of China Medical University,China Medical University,Shenyang,Liaoning,China
3.Department of Cardiology,Renmin Hospital of Wuhan University,Wuchang, Wuhan,430060,China
4.Hubei Key Laboratory of Cardiology,Wuchang, Wuhan,430060,China
5.Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing,38# Xueyuan Road, Haidian District,100191,China
6.Key Laboratory of Epidemiology of Major Diseases (Peking University),Ministry of Education,Beijing,China
7.Department of Cardiology,Kailuan General Hospital,Tangshan,No.57 Xinhua East Road, Hebei Province,063000,China
8.Hypertension Center,State Key Laboratory of Cardiovascular Disease of China,National Center for Cardiovascular Diseases of China,Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100037,China
9.Department of Cardiology,Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Center,The Second Clinical Medical College,The First Affiliated Hospital,Shenzhen People’s Hospital,Jinan University,Southern University of Science and Technology),Shenzhen,Guangdong,518020,China

Zhong，Jiwen,Jiang，Jinguo,Guo，Liang,等. 10-year trajectory of Life’s Essential 8 and incident hypertension: a community-based cohort study[J]. Lipids in Health and Disease,2024,23(1).

Zhong，Jiwen.,Jiang，Jinguo.,Guo，Liang.,Liu，Yang.,Wu，Shouling.,...&Zheng，Wei.(2024).10-year trajectory of Life’s Essential 8 and incident hypertension: a community-based cohort study.Lipids in Health and Disease,23(1).

Zhong，Jiwen,et al."10-year trajectory of Life’s Essential 8 and incident hypertension: a community-based cohort study".Lipids in Health and Disease 23.1(2024).