南方科技大学知识苑(SUSTech KC): Cathepsin B in cardiovascular disease: Underlying mechanisms and therapeutic strategies

题名	Cathepsin B in cardiovascular disease: Underlying mechanisms and therapeutic strategies
作者	Cai, Zhulan 1; Xu, Shunyao 2; Liu, Chen 3
通讯作者	Xu, Shunyao; Liu, Chen
发表日期	2024-09-01
DOI	10.1111/jcmm.70064
发表期刊	JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 影响因子和分区
ISSN	1582-1838
EISSN	1582-4934
卷号	28 期号:17
摘要	Cathepsin B (CTSB) is a member of the cysteine protease family, primarily responsible for degrading unnecessary organelles and proteins within the acidic milieu of lysosomes to facilitate recycling. Recent research has revealed that CTSB plays a multifaceted role beyond its function as a proteolytic enzyme in lysosomes. Importantly, recent data suggest that CTSB has significant impacts on different cardiac pathological conditions, such as atherosclerosis (AS), myocardial infarction, hypertension, heart failure and cardiomyopathy. Especially in the context of AS, preclinical models and clinical sample imaging data indicate that the cathepsin activity-based probe can reliably image CTSB activity in foam cells and atherosclerotic plaques; concurrently, it allows synchronous diagnostic and therapeutic interventions. However, our knowledge of CTSB in cardiovascular disease is still in the early stage. This paper aims to provide a comprehensive review of the significance of CTSB in cardiovascular physiology and pathology, with the objective of laying a theoretical groundwork for the development of drugs targeting CTSB.
关键词	atherosclerosis cardiomyopathy cardiovascular diseases cathepsin B heart failure hypertension myocardial infarction therapeutic strategies
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	National Natural Science Foundation of China["82200301","82202381"] ; Sanming Project of Medicine in Shenzhen[SZSN202311007] ; null[JCYJ20210324102608023] ; null[RCBS20210609103154055]
WOS研究方向	Cell Biology ; Research & Experimental Medicine
WOS类目	Cell Biology ; Medicine, Research & Experimental
WOS记录号	WOS:001307802600001
出版者	WILEY
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/828630
专题	南方科技大学第一附属医院
作者单位	1.Peking Univ Third Hosp, Dept Cardiol, Beijing, Peoples R China 2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2,Dept Crit Care,Affiliated Hosp 1, Shenzhen, Peoples R China 3.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Dept Geriatr, Shenzhen, Peoples R China
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Cai, Zhulan,Xu, Shunyao,Liu, Chen. Cathepsin B in cardiovascular disease: Underlying mechanisms and therapeutic strategies[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2024,28(17).
APA	Cai, Zhulan,Xu, Shunyao,&Liu, Chen.(2024).Cathepsin B in cardiovascular disease: Underlying mechanisms and therapeutic strategies.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,28(17).
MLA	Cai, Zhulan,et al."Cathepsin B in cardiovascular disease: Underlying mechanisms and therapeutic strategies".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 28.17(2024).