3D-Printed Hydrogels with Engineered Nanocrystalline Domains as Functional Vascular Constructs

Ye, Tan1,2,3,4; Chai, Muyuan5; Wang, Zhenxing1,2,3,4; Shao, Tingru6; Liu, Ji7; Shi, Xuetao1,2,3,4

2024-09-01

10.1021/acsnano.4c08359

ACS NANO   影响因子和分区

1936-0851

1936-086X

Three-dimensionally printed (3DP) hydrogel-based vascular constructs have been investigated in response to the impaired function of blood vessels or organs by replicating exactly the 3D structural geometry to approach their function. However, they are still challenged by their intrinsic brittleness, which could not sustain the suture piercing and enable the long-term structural and functional stability during the direct contact with blood. Here, we reported the high-fidelity digital light processing (DLP) 3D printing of hydrogel-based vascular constructs from poly(vinyl alcohol)-based inks, followed by mechanical strengthening through engineering the nanocrystalline domains and subsequent surface modification. The as-prepared high-precision hydrogel vascular constructs were imparted with highly desirable mechanical robustness, suture tolerance, swelling resistance, antithrombosis, and long-term patency. Notably, the hydrogel-based bionic vein grafts, with precise valve structures, exhibited excellent control over the unidirectional flow and successfully fulfilled the biological functionalities and patency during a 4-week implantation within the deep veins of beagles, thus corroborating the promising potential for treating chronic venous insufficiency.

hydrogels 3D printing nanocrystallinedomains vascular constructs venous valves

SCI

英语

通讯

National Key Research and Development Program of China[2021YFB3800800] ; National Natural Science Foundation of China["T2288101","U22A20157","82002882","52342211","52373139"] ; Guangdong Basic and Applied Basic Research Foundation["2022B1515130010","2023A1515110794","2024B1515040030","2022A1515010152"] ; Talent Recruitment Program of Guangdong Province[2019QN01Y576] ; Postdoctoral Fellowship Program of CPSF[GZC20231080]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:001306501500001

AMER CHEMICAL SOC

Web of Science

1.South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou 510006, Peoples R China
2.South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510640, Peoples R China
3.South China Univ Technol, Key Lab Biomed Engn Guangdong Prov, Guangzhou 510006, Peoples R China
4.South China Univ Technol, Minist Educ, Key Lab Biomed Mat & Engn, Guangzhou 510006, Peoples R China
5.Southern Med Univ, Affiliated Hosp 10, Dongguan Key Lab Smart Biomat & Regenerat Med, Dongguan 523000, Peoples R China
6.Southern Med Univ, Zhujiang Hosp, Dept Oral & Maxillofacial Surg, Guangzhou 510280, Peoples R China
7.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Peoples R China

Ye, Tan,Chai, Muyuan,Wang, Zhenxing,et al. 3D-Printed Hydrogels with Engineered Nanocrystalline Domains as Functional Vascular Constructs[J]. ACS NANO,2024.

Ye, Tan,Chai, Muyuan,Wang, Zhenxing,Shao, Tingru,Liu, Ji,&Shi, Xuetao.(2024).3D-Printed Hydrogels with Engineered Nanocrystalline Domains as Functional Vascular Constructs.ACS NANO.

Ye, Tan,et al."3D-Printed Hydrogels with Engineered Nanocrystalline Domains as Functional Vascular Constructs".ACS NANO (2024).