Autologous exosomes loaded with a rationally designed photosensitizer for enhanced photodynamic therapy

Qian, Yuhan; Li, Chong; Gao, Ji; Wang, Shuxian; Wu, Xue; Wei, Luyao; Zha, Menglei; Shi, Yuxin; Kang, Tianyi; Li, Kai

2024-08-01

10.1039/d4cc02168a

CHEMICAL COMMUNICATIONS   影响因子和分区

1359-7345

1364-548X

["We present generalizing statistical surrogate models to select an optimized photosensitizer, TPP, which is subsequently loaded into autologous exosomes by ultrasonic mixing to achieve tumor targeting with enhanced therapeutic efficacy by photodynamic therapy (PDT). This work contributes to the exploration of PDT enhancement strategies, and provides new prospects for using autologous exosomes as a delivery system.","We present generalizing statistical surrogate models to optimize photosensitizer selection and enhance photodynamic therapy efficacy by encapsulating it into autologous exosomes."]

SCI

英语

第一 ; 通讯

Ministry of Science and Technology of China["2020YFA0908900","2023YFF0715400"] ; National Natural Science Foundation of China[U21A2097] ; Department of Science and Technology of Guangdong Province["2019ZT08Y191","2019QN01Y640","2022B1212010003"]

Chemistry

Chemistry, Multidisciplinary

WOS:001298409500001

ROYAL SOC CHEMISTRY

Web of Science

Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China

Qian, Yuhan,Li, Chong,Gao, Ji,et al. Autologous exosomes loaded with a rationally designed photosensitizer for enhanced photodynamic therapy[J]. CHEMICAL COMMUNICATIONS,2024.

Qian, Yuhan.,Li, Chong.,Gao, Ji.,Wang, Shuxian.,Wu, Xue.,...&Li, Kai.(2024).Autologous exosomes loaded with a rationally designed photosensitizer for enhanced photodynamic therapy.CHEMICAL COMMUNICATIONS.

Qian, Yuhan,et al."Autologous exosomes loaded with a rationally designed photosensitizer for enhanced photodynamic therapy".CHEMICAL COMMUNICATIONS (2024).