Network analysis of depressive symptoms and C-reactive protein levels in major depressive disorder

Wang，Dongfang1,2; Xu，Jianchang3; Liang，Nana3; Xue，Zhenpeng3; Yang，Xiujuan3; Lu，Jianping3; Ma，Yuejiao3

2024-12-15

10.1016/j.jad.2024.08.152

Journal of Affective Disorders   影响因子和分区

0165-0327

1573-2517

Background: C-reactive protein (CRP) levels have been implicated in the severity and symptomatology of major depressive disorder (MDD). The aim of this study was to explore the structure of depressive symptoms in patients with MDD according to different groups of CRP levels using network analysis. Methods: The study included 864 individuals (mean age = 54.05, 67.48 % male) diagnosed with MDD from the 2015–2020 National Health and Nutrition Examination Survey (NHANES). Analyses examined how depressive symptoms and CRP level were related to each other, and how the network structure of depressive symptoms differed across groups with different CRP levels. Results: A direct positive correlation was observed between CRP levels and specific depressive symptoms (e.g., appetite change, energy loss, and feelings of worthlessness). Moreover, there was a stronger correlation between depressive symptoms in the medium CRP and high CRP groups compared to the low CRP group. Furthermore, it was observed that there were notable structural differences between the high-CRP and moderate-CRP groups. Limitations: The study is based on cross-sectional data, which precludes the drawing of causal conclusions. Furthermore, it does not take into account confounding factors such as body mass index (BMI) and lifestyle. Conclusions: The findings underscore the pivotal role of CRP as a marker of the severity of depressive symptoms. Routine CRP level testing and anti-inflammatory therapies may be beneficial for depressed patients with elevated CRP levels in clinical practice.

Depressive symptoms High-sensitivity C-reactive protein Major depressive disorder Nnetwork analysis

英语

通讯

2-s2.0-85203633296

Scopus

1.Department of Psychiatry,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,China
2.Technical University of Munich,TUM School of Medicine and Health,Klinikum rechts der Isar,Department of Psychiatry and Psychotherapy,Munich,Germany
3.Department of Child and Adolescent Psychiatry,Shenzhen Kangning Hospital,Shenzhen Institute of Mental Health,Shenzhen Mental Health Center,Affiliated Mental Health Center,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China

Wang，Dongfang,Xu，Jianchang,Liang，Nana,et al. Network analysis of depressive symptoms and C-reactive protein levels in major depressive disorder[J]. Journal of Affective Disorders,2024,367:788-794.

Wang，Dongfang.,Xu，Jianchang.,Liang，Nana.,Xue，Zhenpeng.,Yang，Xiujuan.,...&Ma，Yuejiao.(2024).Network analysis of depressive symptoms and C-reactive protein levels in major depressive disorder.Journal of Affective Disorders,367,788-794.

Wang，Dongfang,et al."Network analysis of depressive symptoms and C-reactive protein levels in major depressive disorder".Journal of Affective Disorders 367(2024):788-794.