Co-delivery of siRNA and cisplatin via electrospun Nanofibrous membranes for synergistic treatment of malignant melanoma

Zhang, Xuewei1,2; Zheng, Guoxing3; Zhou, Zibin3; Zhu, Mingyu4,5; Tang, Shijie1,2,4

2024-09-15

10.1016/j.heliyon.2024.e37517

HELIYON   影响因子和分区

2405-8440

Tumor recurrence and metastasis remain formidable challenges in clinical oncology. Although surgery is an effective treatment for early-stage solid tumors, residual cancer cells can lead to subsequent recurrence or metastasis. Conventional treatments for melanoma, such as anti-tumor medications and gene therapy, have distinct limitations. The rapid systemic distribution of antitumor drugs poses a significant challenge, often resulting in notable side effects and inadequate drug concentrations at the tumor site. Melanoma (MM), a deadly form of skin cancer, is known for its high mortality rate. In this study, we propose a novel strategy for treating MM by combining the controlled release of chemotherapeutic drugs encapsulated within Metal-Organic Frameworks (MOFs) and liposomes with gene therapy targeting Minichromosome Maintenance Proteins 4 (MCM4) using electrospinning and surface modification techniques. In vitro and in vivo results confirmed that this hierarchical membrane system can effectively deliver therapeutic MCM4 siRNA and release cisplatin to inhibit tumor growth. Furthermore, we demonstrated that MCM4 silencing promoted the sensitivity of melanoma cells to ferroptosis both in vitro and in vivo. The proposed strategy, by allowing for a controlled and sustained release of medication, could alleviate the challenges in drug delivery and aid in prevent tumor recurrence.

Malignant melanoma Drug delivery Ferroptosis Nano fiber Gene therapy

SCI

英语

通讯

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:001312228100001

CELL PRESS

Web of Science

1.Shantou Univ, Affiliated Hosp 2, Med Coll, Dept Plast Surg, Shantou 515000, Guangdong, Peoples R China
2.Shantou Univ, Affiliated Hosp 2, Med Coll, Burn Ctr, Shantou 515000, Guangdong, Peoples R China
3.Shantou Univ, Affiliated Hosp 2, Med Coll, Dept Spine Surg, Shantou 515000, Guangdong, Peoples R China
4.Univ Helsinki, Fac Pharm, Div Pharmaceut Chem & Technol, Helsinki 00014, Finland
5.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China

Zhang, Xuewei,Zheng, Guoxing,Zhou, Zibin,et al. Co-delivery of siRNA and cisplatin via electrospun Nanofibrous membranes for synergistic treatment of malignant melanoma[J]. HELIYON,2024,10(17).

Zhang, Xuewei,Zheng, Guoxing,Zhou, Zibin,Zhu, Mingyu,&Tang, Shijie.(2024).Co-delivery of siRNA and cisplatin via electrospun Nanofibrous membranes for synergistic treatment of malignant melanoma.HELIYON,10(17).

Zhang, Xuewei,et al."Co-delivery of siRNA and cisplatin via electrospun Nanofibrous membranes for synergistic treatment of malignant melanoma".HELIYON 10.17(2024).