Protein nanopore-based sensors for public health analyte detection

Zhang, Yanhua1; Hu, Chan1; Liu, Ronghui2; He, Shujun1; Yang, Jie1; Yao, Wen1; Li, Yi2; Guo, Xinrong1

2024-09-01

10.1039/d4tb01149j

JOURNAL OF MATERIALS CHEMISTRY B   影响因子和分区

2050-750X

2050-7518

["High-throughput and label-free protein nanopore-based sensors are extensively used in DNA sequencing, single-protein analysis, molecular sensing and chemical catalysis with single channel recording. These technologies show great potential for identifying various harmful substances linked to public health by addressing the limitations of current portability and the speed of existing techniques. In this review, we provide an overview of the fundamental principles of nanopore sensing, with a focus on chemical modification and genetic engineering strategies aimed at enhancing the detection sensitivity and identification accuracy of protein nanopores. The engineered protein nanopores enable direct sensing, while the introduction of aptamers and substrates enables indirect sensing, translating the physical structure and chemical properties of analytes into readable signals. These scientific discoveries and engineering efforts have provided new prospects for detecting and monitoring trace hazardous substances.","High-throughput and label-free protein nanopore-based sensors with engineering strategies are extensively used to identify public health hazardous substances with single channel recording."]

SCI

英语

通讯

Basic and Applied Basic Research Foundation of Guangdong Province[JCYJ20230807092459028] ; Science and Technology Innovation Commission of Shenzhen["82404318","32371526"] ; National Natural Science Foundation of China[2022A1515140191] ; Guangdong Basic and Applied Basic Research Foundation[A2024159] ; Guangdong Medical Science and Technology Research Fund Project[GDMUB2021004]

Materials Science

Materials Science, Biomaterials

WOS:001309581800001

ROYAL SOC CHEMISTRY

Web of Science

1.Guangdong Med Univ, Sch Publ Hlth, Dongguan Key Lab Publ Hlth Lab Sci, Dongguan 523808, Peoples R China
2.Southern Univ Sci & Technol, Sch Microelect, Shenzhen 518055, Peoples R China

Zhang, Yanhua,Hu, Chan,Liu, Ronghui,et al. Protein nanopore-based sensors for public health analyte detection[J]. JOURNAL OF MATERIALS CHEMISTRY B,2024.

Zhang, Yanhua.,Hu, Chan.,Liu, Ronghui.,He, Shujun.,Yang, Jie.,...&Guo, Xinrong.(2024).Protein nanopore-based sensors for public health analyte detection.JOURNAL OF MATERIALS CHEMISTRY B.

Zhang, Yanhua,et al."Protein nanopore-based sensors for public health analyte detection".JOURNAL OF MATERIALS CHEMISTRY B (2024).