| 题名 | The burgeoning spatial multi-omics in human gastrointestinal cancers |
| 作者 | |
| 通讯作者 | Zhi, Xuejun; Ran, Rensen |
| 发表日期 | 2024-09-13
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| DOI | |
| 发表期刊 | |
| ISSN | 2167-8359
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| 卷号 | 12 |
| 摘要 | The development and progression of diseases in multicellular organisms unfold within the intricate three-dimensional body environment. Thus, to comprehensively understand the molecular mechanisms governing individual development and disease progression, precise acquisition of biological data, including genome, transcriptome, proteome, metabolome, and epigenome, with single-cell resolution and spatial information within the body's three-dimensional context, is essential. This foundational information serves as the basis for deciphering cellular and molecular mechanisms. Although single-cell multi-omics technology can provide biological information such as genome, transcriptome, proteome, metabolome, and epigenome with single-cell resolution, the sample preparation process leads to the loss of spatial information. Spatial multi-omics technology, however, facilitates the characterization of biological data, such as genome, transcriptome, proteome, metabolome, and epigenome in tissue samples, while retaining their spatial context. Consequently, these techniques significantly enhance our understanding of individual development and disease pathology. Currently, spatial multi-omics technology has played a vital role in elucidating various processes in tumor biology, including tumor occurrence, development, and metastasis, particularly in the realms of tumor immunity and the heterogeneity of the tumor microenvironment. Therefore, this article provides a comprehensive overview of spatial transcriptomics, spatial proteomics, and spatial metabolomics-related technologies and their application in research concerning esophageal cancer, gastric cancer, and colorectal cancer. The objective is to foster the research and implementation of spatial multi-omics technology in digestive tumor diseases. This review will provide new technical insights for molecular biology researchers. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 资助项目 | Zhangjiakou City Key RD Plan Project["2322088D","2311038D"]
; Hebei Provincial Natural Science Foundation[H2022405033]
; Hebei Province Key RD Plan Project[22377784D]
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| WOS研究方向 | Science & Technology - Other Topics
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| WOS类目 | Multidisciplinary Sciences
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| WOS记录号 | WOS:001316501400001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/834218 |
| 专题 | 理学院_化学系 生命科学学院 生命科学学院_化学生物学系 |
| 作者单位 | 1.Hebei North Univ, Affiliated Hosp 1, Cent Lab, Zhangjiakou, Hebei Province, Peoples R China 2.Hebei North Univ, Affiliated Hosp 1, Dept Surg, Zhangjiakou, Hebei Province, Peoples R China 3.Hebei North Univ, Zhangjiakou, Hebei Province, Peoples R China 4.Hebei North Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Zhangjiakou, Hebei Province, Peoples R China 5.Southern Univ Sci & Technol, Sch Life Sci, Dept Chem Biol, Shenzhen, Peoples R China |
| 通讯作者单位 | 化学系; 化学生物学系; 生命科学学院 |
| 推荐引用方式 GB/T 7714 |
Liang, Weizheng,Zhu, Zhenpeng,Xu, Dandan,et al. The burgeoning spatial multi-omics in human gastrointestinal cancers[J]. PEERJ,2024,12.
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| APA |
Liang, Weizheng.,Zhu, Zhenpeng.,Xu, Dandan.,Wang, Peng.,Guo, Fei.,...&Ran, Rensen.(2024).The burgeoning spatial multi-omics in human gastrointestinal cancers.PEERJ,12.
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| MLA |
Liang, Weizheng,et al."The burgeoning spatial multi-omics in human gastrointestinal cancers".PEERJ 12(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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