| 题名 | Migfilin promotes autophagic flux through direct interaction with SNAP29 and Vamp8 |
| 作者 | |
| 通讯作者 | Wu, Chuanyue; Sun, Ying |
| 发表日期 | 2024-09-16
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| DOI | |
| 发表期刊 | |
| ISSN | 0021-9525
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| EISSN | 1540-8140
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| 卷号 | 223期号:11 |
| 摘要 | ["This study reveals a novel function of migfilin in regulating autophagosome-lysosome fusion by interacting with SNAP29 and Vamp8. Migfilin enhances Stx17-SNAP29-Vamp8 assembly, which induces autophagic flux and further promotes cancer progression. Targeting migfilin-SNARE assembly could be exploited therapeutically for cancer treatment.","Autophagy plays a crucial role in cancer cell survival by facilitating the elimination of detrimental cellular components and the recycling of nutrients. Understanding the molecular regulation of autophagy is critical for developing interventional approaches for cancer therapy. In this study, we report that migfilin, a focal adhesion protein, plays a novel role in promoting autophagy by increasing autophagosome-lysosome fusion. We found that migfilin is associated with SNAP29 and Vamp8, thereby facilitating Stx17-SNAP29-Vamp8 SNARE complex assembly. Depletion of migfilin disrupted the formation of the SNAP29-mediated SNARE complex, which consequently blocked the autophagosome-lysosome fusion, ultimately suppressing cancer cell growth. Restoration of the SNARE complex formation rescued migfilin-deficiency-induced autophagic flux defects. Finally, we found depletion of migfilin inhibited cancer cell proliferation. SNARE complex reassembly successfully reversed migfilin-deficiency-induced inhibition of cancer cell growth. Taken together, our study uncovers a new function of migfilin as an autophagy-regulatory protein and suggests that targeting the migfilin-SNARE assembly could provide a promising therapeutic approach to alleviate cancer progression."] |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 第一
; 通讯
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| WOS研究方向 | Cell Biology
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| WOS类目 | Cell Biology
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| WOS记录号 | WOS:001313732800001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/834247 |
| 专题 | 南方科技大学医学院 南方科技大学 生命科学学院 理学院_化学系 |
| 作者单位 | 1.Southern Univ Sci & Technol, Guangdong Prov Key Lab Cell Microenvironm & Dis Re, Shenzhen Key Lab Cell Microenvironm, Dept Syst Biol,Sch Life Sci, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen, Peoples R China 3.Southern Univ Sci & Technol, Coll Sci, Res Ctr Chem Biol & Omics Anal, Shenzhen, Peoples R China 4.Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15213 USA 5.Univ Pittsburgh, Canc Inst, Pittsburgh, PA 15213 USA |
| 第一作者单位 | 南方科技大学医学院; 生命科学学院 |
| 通讯作者单位 | 南方科技大学医学院; 生命科学学院; 南方科技大学 |
| 第一作者的第一单位 | 南方科技大学医学院; 生命科学学院 |
| 推荐引用方式 GB/T 7714 |
Cai, Renwei,Bai, Panzhu,Quan, Meiling,et al. Migfilin promotes autophagic flux through direct interaction with SNAP29 and Vamp8[J]. JOURNAL OF CELL BIOLOGY,2024,223(11).
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| APA |
Cai, Renwei.,Bai, Panzhu.,Quan, Meiling.,Ding, Yanyan.,Wei, Wenjie.,...&Sun, Ying.(2024).Migfilin promotes autophagic flux through direct interaction with SNAP29 and Vamp8.JOURNAL OF CELL BIOLOGY,223(11).
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| MLA |
Cai, Renwei,et al."Migfilin promotes autophagic flux through direct interaction with SNAP29 and Vamp8".JOURNAL OF CELL BIOLOGY 223.11(2024).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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