Specific persistent symptoms of COVID-19 and associations with reinfection: a community-based survey study in southern China

Liu, Dongjing1,2; Chen, Binglin3; Liao, Xuejiao1,2; Zhang, Zheng1,2; Wei, Sen4; Han, Xinxin3; Xu, Yong1

2024-09-03

10.3389/fpubh.2024.1452233

FRONTIERS IN PUBLIC HEALTH   影响因子和分区

2296-2565

Background Surveillance remains fundamental to understanding the changes in epidemiological patterns regarding post-COVID conditions and reinfections. Persistent symptoms and reinfection in previously infected individuals are increasing being reported in many countries, but their associations among general populations were seldomly reported. Understanding the association with persistent symptoms of COVID-19 reinfection is essential to develop strategies to mitigate the long-term health and socio-economic impacts of the post-COVID conditions. This study aimed to investigate the incidence of COVID-19 persistent symptoms among previously infected Chinese community residents and explore associations of specific COVID-19 persistent symptoms with reinfection and other factors.Methods A community-based survey was conducted in a southern city of China with about 20 million residents from August 3 to 24, 2023. Face-to-face questionnaires were distributed to a total of 1,485 residents to collect their information about COVID-19 infection, reinfection, specific ongoing persistent symptoms, and other COVID-19 related information. Multivariable logistic regression analysis was used to examine the association between specific persistent symptoms and reinfection of COVID-19, along with age, gender, and educational level.Results Of the 1,485 participants, 1,089 (73.3%) reported they had been infected with COVID-19. Among them, 89.1% reported having ongoing persistent symptoms and 14.2% reported had two or more times of infection. About 20% participants were infected 1 year or more since their initial infection. Fatigue, cough, and headaches were the top 3 symptoms being reported. Participants with reinfection were associated with a higher probability of reporting headaches (OR: 1.54, 95% CI: 1.06-2.25), loss of or change in smell and/or taste (OR: 1.90, 95% CI: 1.27-2.83), impaired sleep (OR: 1.55, 95% CI: 1.02-2.35), and brain fog (OR: 1.76, 95% CI: 1.12-2.76). Participants aged 45 and above and who had a bachelor's or higher degree were more likely to report chest tightness or shortness of breath, impaired sleep, and brain fog.Discussion During the post-emergency period of COVID-19 pandemic, the incidence of ongoing persistent symptoms among Chinese residents remains high. Individuals whose initial infection was longer than 1 year have the highest probability of reporting having multiple symptoms. Reinfection may increase the risk of reporting headaches, loss of or change in smell and/or taste, impaired sleep, and brain fog. It is important to maintain routine syndromic surveillance among previously infected people and provide recommendations for clinical management of individuals with multiple ongoing symptoms.

infectious disease COVID-19 reinfection persistent symptoms community-based surveillance

SCI ; SSCI

英语

通讯

Chinese Academy of Medical Sciences Clinical and Translational Medicine Research Project[2022-I2M-CT-B-113] ; Shenzhen Science and Technology Innovation Committee[No.JSGG20220226090002003]

Public, Environmental & Occupational Health

Public, Environmental & Occupational Health

WOS:001313367200001

FRONTIERS MEDIA SA

Web of Science

1.Third Peoples Hosp Shenzhen, Shenzhen, Peoples R China
2.Chinese Acad Med Sci, Shenzhen Res Ctr Communicable Dis Diag & Treatment, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China
4.Longgang Dist Publ Hlth Serv Ctr, Shenzhen, Peoples R China

Liu, Dongjing,Chen, Binglin,Liao, Xuejiao,et al. Specific persistent symptoms of COVID-19 and associations with reinfection: a community-based survey study in southern China[J]. FRONTIERS IN PUBLIC HEALTH,2024,12.

Liu, Dongjing.,Chen, Binglin.,Liao, Xuejiao.,Zhang, Zheng.,Wei, Sen.,...&Xu, Yong.(2024).Specific persistent symptoms of COVID-19 and associations with reinfection: a community-based survey study in southern China.FRONTIERS IN PUBLIC HEALTH,12.

Liu, Dongjing,et al."Specific persistent symptoms of COVID-19 and associations with reinfection: a community-based survey study in southern China".FRONTIERS IN PUBLIC HEALTH 12(2024).