南方科技大学知识苑(SUSTech KC): The siEGFR nanoplexes for the enhanced brain glioma treatment: Endoplasmic reticulum biomimetic strategy to induce homing effect and non-degradable intracellular transport

题名	The siEGFR nanoplexes for the enhanced brain glioma treatment: Endoplasmic reticulum biomimetic strategy to induce homing effect and non-degradable intracellular transport
作者	Tu, Qingchao 1,2,3; Xia, Fei 1,2; Meng, Yuqing 1,2; Wang, Chen 1,2; Zhang, Hao 1,2; Yao, Hailu 1,2; Fu, Yuanfeng 1,2; Guo, Pengbo 1,2; Chen, Weiqi 1,2; Zhou, Xinyu 1,2; Zhou, Li 1,2; Gan, Licheng 1,2; Wang, Jigang 1,2,3,4; Han, Guang 3; Qiu, Chong 1,2
通讯作者	Wang, Jigang; Han, Guang; Qiu, Chong
发表日期	2024-10-01
DOI	10.1016/j.biopha.2024.117413
发表期刊	BIOMEDICINE & PHARMACOTHERAPY 影响因子和分区
ISSN	0753-3322
EISSN	1950-6007
卷号	179
摘要	The epidermal growth factor receptor (EGFR) plays a pivotal role in tumor progression and is an essential therapeutic target for treating malignant gliomas. Small interfering RNA (siRNA) has the potential to selectively degrade EGFR mRNA, yet its clinical utilization is impeded by various challenges, such as inefficient targeting and limited escape from lysosomes. Our research introduces polyethylene glycol (PEG) and endoplasmic reticulum membrane-coated siEGFR nanoplexes (PEhCv/siEGFR NPs) as an innovative approach to brain glioma therapy by overcoming several obstacles: 1) Tumor-derived endoplasmic reticulum membrane modifications provide a homing effect, facilitating targeted accumulation and cellular uptake; 2) Endoplasmic reticulum membrane proteins mediate a non-degradable "endosome-Golgi-endoplasmic reticulum" transport pathway, circumventing lysosomal degradation. These nanoplexes demonstrated significantly enhanced siEGFR gene silencing in both in vitro and in vivo U87 glioma models. The findings of this study pave the way for the advanced design and effective application of nucleic acid-based therapeutic nanocarriers.
关键词	Nanoplexes Delivery SiRNA Brain Glioma Endoplasmic reticulum membrane
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Central Public Welfare Research Institutes["ZZ14-YQ-055","ZZ16-ND-10-05","ZZ16-ND-10-17","ZZ16-ND-10-13","ZZ16-ND-10-19","ZZ14-YQ-059","ZZ14-YQ-060","ZZ16-YQ-046"] ; Young Elite Scientists Sponsorship Program by CACM[2021QNRC2B29]
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS记录号	WOS:001313749300001
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/834270
专题	南方科技大学第一附属医院
作者单位	1.China Acad Chinese Med Sci, Artemisinin Res Ctr, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100700, Peoples R China 2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 3.Henan Univ, Sch Pharm, State Key Lab Antiviral Drugs, Kaifeng 475004, Peoples R China 4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Jinan Univ,Clin Med Coll 2,Dept Nephrol,Guangdong, Shenzhen 518020, Peoples R China
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Tu, Qingchao,Xia, Fei,Meng, Yuqing,et al. The siEGFR nanoplexes for the enhanced brain glioma treatment: Endoplasmic reticulum biomimetic strategy to induce homing effect and non-degradable intracellular transport[J]. BIOMEDICINE & PHARMACOTHERAPY,2024,179.
APA	Tu, Qingchao.,Xia, Fei.,Meng, Yuqing.,Wang, Chen.,Zhang, Hao.,...&Qiu, Chong.(2024).The siEGFR nanoplexes for the enhanced brain glioma treatment: Endoplasmic reticulum biomimetic strategy to induce homing effect and non-degradable intracellular transport.BIOMEDICINE & PHARMACOTHERAPY,179.
MLA	Tu, Qingchao,et al."The siEGFR nanoplexes for the enhanced brain glioma treatment: Endoplasmic reticulum biomimetic strategy to induce homing effect and non-degradable intracellular transport".BIOMEDICINE & PHARMACOTHERAPY 179(2024).