Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis

Liu, Lei1; He, Gang1; Li, Yixi1; Xian, Yiwen1; He, Guixian2; Hong, Yonglong2; Zhang, Chong1; Wu, Decheng1

2024-09-06

10.34133/bmr.0073

BIOMATERIALS RESEARCH   影响因子和分区

1226-4601

2055-7124

The pathogenesis of temporomandibular joint osteoarthritis (TMJOA) is closely associated with mechanical friction, which leads to the up-regulation of inflammatory mediators and the degradation of articular cartilage. Injectable drug-loaded microparticles have attracted widespread interest in intra-articular treatment of TMJOA by providing lubrication and facilitating localized drug delivery. Herein, a hyaluronic acid-based microparticle is developed with excellent lubrication properties, drug loading capacity, antioxidant activity, and anti-inflammatory effect for the treatment of TMJOA. The microparticles are facilely prepared by the self-assembly of 3-aminophenylboronic acid-modified hyaluronic acid (HP) through hydrophobic interaction in an aqueous solution, which can further encapsulate diol-containing drugs through dynamic boronate ester bonds. The resulting microparticles demonstrate excellent injectability, lubrication properties, radical scavenging efficiency, and antibacterial activity. Additionally, the drug-loaded microparticles exhibit a favorable cytoprotective effect on chondrocyte cells in vitro under an oxidative stress microenvironment. In vivo experiments validate that intra-articular injection of drug-loaded microparticles effectively alleviates osteoporosis-like damage, suppresses inflammatory response, and facilitates matrix regeneration in the treatment of TMJOA. The HP microparticles demonstrate excellent injectability and encapsulation capacity for diol-containing drugs, highlighting its potential as a versatile drug delivery vehicle in the intra-articular treatment of TMJOA.

SCI

英语

第一 ; 通讯

Ministry of Science and Technology of China[2020YFA0908900] ; National Natural Science Foundation of China[21935011] ; Shenzhen Science and Technology Innovation Commission["KQTD20200820113012029","JCYJ20220818100601003","JCYJ20190814114605162"] ; Guangdong Basic and Applied Basic Research Foundation["2022A-1515110321","2024A1515011621"] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:001314000700001

AMER ASSOC ADVANCEMENT SCIENCE

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China
2.Southern Med Univ, Shenzhen Hosp, Dept Maxillofacial Surg, Shenzhen 518101, Peoples R China

Liu, Lei,He, Gang,Li, Yixi,et al. Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis[J]. BIOMATERIALS RESEARCH,2024,28.

Liu, Lei.,He, Gang.,Li, Yixi.,Xian, Yiwen.,He, Guixian.,...&Wu, Decheng.(2024).Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis.BIOMATERIALS RESEARCH,28.

Liu, Lei,et al."Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis".BIOMATERIALS RESEARCH 28(2024).